Abstract
Breast cancer is one of the most common causes of the death among women worldwide. Metabolic disorders, alcohol consumption, hormone replacement therapy, genetic susceptibility and not having children are well known risk factors for breast cancer. Surgical resection, radiation therapy, and chemotherapy are among the limited treatment options for breast cancer. Thus, there is growing need to find new chemopreventive agents that may be effective in prevention and/or management of breast cancer. Natural products such as flavonoids provide a variety of anticancer compounds which can be useful for prevention or treatment of breast cancer. The usefulness of dietary phytochemicals in the prevention of this disease is supported by a plethora of experimental and epidemiological studies. Apigenin, a well-known flavone, is found in several dietary plant foods such as parsley, celery, thyme, celeriac, chamomile, onions, lemon balm, and oranges. Extensive studies have shown that apigenin have potent antioxidant, anti-inflammatory, and anticarcinogenic properties. The aim of the present communication is to establish the therapeutic potential of apigenin against breast cancer through critical analysis of data from 5 in vitro and in vivo studies. We also review the molecular mechanisms underlying the anticancer effects, natural sources, bioavailability, as well as the chemistry of apigenin.
Keywords: Apigenin, apoptosis, aromatase activity, breast cancer.
Anti-Cancer Agents in Medicinal Chemistry
Title:Apigenin and Breast Cancers: From Chemistry to Medicine
Volume: 15 Issue: 6
Author(s): Seyed Mohammad Nabavi, Solomon Habtemariam, Maria Daglia and Seyed Fazel Nabavi
Affiliation:
Keywords: Apigenin, apoptosis, aromatase activity, breast cancer.
Abstract: Breast cancer is one of the most common causes of the death among women worldwide. Metabolic disorders, alcohol consumption, hormone replacement therapy, genetic susceptibility and not having children are well known risk factors for breast cancer. Surgical resection, radiation therapy, and chemotherapy are among the limited treatment options for breast cancer. Thus, there is growing need to find new chemopreventive agents that may be effective in prevention and/or management of breast cancer. Natural products such as flavonoids provide a variety of anticancer compounds which can be useful for prevention or treatment of breast cancer. The usefulness of dietary phytochemicals in the prevention of this disease is supported by a plethora of experimental and epidemiological studies. Apigenin, a well-known flavone, is found in several dietary plant foods such as parsley, celery, thyme, celeriac, chamomile, onions, lemon balm, and oranges. Extensive studies have shown that apigenin have potent antioxidant, anti-inflammatory, and anticarcinogenic properties. The aim of the present communication is to establish the therapeutic potential of apigenin against breast cancer through critical analysis of data from 5 in vitro and in vivo studies. We also review the molecular mechanisms underlying the anticancer effects, natural sources, bioavailability, as well as the chemistry of apigenin.
Export Options
About this article
Cite this article as:
Nabavi Mohammad Seyed, Habtemariam Solomon, Daglia Maria and Nabavi Fazel Seyed, Apigenin and Breast Cancers: From Chemistry to Medicine, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (6) . https://dx.doi.org/10.2174/1871520615666150304120643
DOI https://dx.doi.org/10.2174/1871520615666150304120643 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Effect of Phase Transition Temperature on Therapeutic Efficacy of Liposomal Bortezomib
Anti-Cancer Agents in Medicinal Chemistry Optimized Model for Cervical Cancer Detection Using Binary Cuckoo Search
Recent Patents on Computer Science Modified-Release Solid Formulations for Colonic Delivery
Recent Patents on Drug Delivery & Formulation Patent Selections:
Current Biomarkers (Discontinued) Celiac Disease: Pathogenesis and Novel Therapeutic Strategies
Endocrine, Metabolic & Immune Disorders - Drug Targets Rapid Fluorimetric Quantitation of Ibandronate by Coupling Quantum Dots and Multicommutated Flow Injection Analysis
Current Pharmaceutical Analysis Computational Identification of microRNA-17-3p in Breast Cancer Cells
MicroRNA Biospecies Capture and Detection at Low Concentration
Micro and Nanosystems Potential Role of <i>In Vitro-In Vivo</i> Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs
Current Drug Targets Novel Small-Molecule Inhibitors of Arylamine N-Acetyltransferases: Drug Discovery by High Throughput Screening
Combinatorial Chemistry & High Throughput Screening DMBA- Induced Breast Cancer: A Hormonal Camouflage
Current Cancer Therapy Reviews Editorial [Hot Topic Ion Fluxes and Cancer (Guest Editors: Luca Munaron and Annarosa Arcangeli)]
Recent Patents on Anti-Cancer Drug Discovery The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans
The Natural Products Journal From Physiome to Pathome: A Systems Biology Model of Major Depressive Disorder and the Psycho-Immune-Neuroendocrine Network
Current Psychiatry Reviews Synthesis and Anti-cancer Activity of 3-substituted Benzoyl-4-substituted Phenyl-1H-pyrrole Derivatives
Anti-Cancer Agents in Medicinal Chemistry Non-steroidal Anti-Inflammatory Drugs and Melanoma
Current Pharmaceutical Design Sex Differences in Alcohol Use Disorder
Current Medicinal Chemistry Peripheral Neuropathy Induced by Paclitaxel: Recent Insights and Future Perspectives
Current Neuropharmacology Dietary Phytochemicals and Endrocrine-related Activities: An Update
Mini-Reviews in Medicinal Chemistry Molecular Imaging of Breast Cancer: Role of RGD Peptides
Mini-Reviews in Medicinal Chemistry