Abstract
A scalable approach for the cyanosilation of benzaldehydes and acetophenones using indium trichloride, a versatile, user friendly catalyst is developed. Cyanohydrin trimethylsilyl ethers are converted in the same pot to α-fluorophenyl acetonitriles which are efficiently reduced to their corresponding amines using sodium borohydride in presence of cerium trichloride.
Keywords: Cyanohydrin silyl ether, indium trichloride, α-fluorophenyl acetonitrile, sodium borohydride, cerium trichloride, DAST.
Graphical Abstract
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