Abstract
In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role of oxidants in numerous pathological conditions such as cancer, the antioxidants developed as therapeutics have been proven ineffective. It is well established that melatonin (MLT) and its metabolites are able to function as endogenous free-radical scavengers and broadspectrum antioxidants. Numerous studies also proved the role of MLT and its derivatives in many physiological processes and therapeutic functions, such as the regulation of circadian rhythm and immune functions. The aim of this review is to arouse attention to MLT as a potentially valuable agent in the prevention and/or treatment of some diseases.
Keywords: Antioxidant, Cancer, Diabetes, Immune system, Inflammatory diseases, Melatonin, Neurodegenerative disorders, Radiation.
Current Topics in Medicinal Chemistry
Title:Antioxidant Properties of Melatonin and its Potential Action in Diseases
Volume: 15 Issue: 9
Author(s): Cigdem Karaaslan and Sibel Suzen
Affiliation:
Keywords: Antioxidant, Cancer, Diabetes, Immune system, Inflammatory diseases, Melatonin, Neurodegenerative disorders, Radiation.
Abstract: In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role of oxidants in numerous pathological conditions such as cancer, the antioxidants developed as therapeutics have been proven ineffective. It is well established that melatonin (MLT) and its metabolites are able to function as endogenous free-radical scavengers and broadspectrum antioxidants. Numerous studies also proved the role of MLT and its derivatives in many physiological processes and therapeutic functions, such as the regulation of circadian rhythm and immune functions. The aim of this review is to arouse attention to MLT as a potentially valuable agent in the prevention and/or treatment of some diseases.
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Cite this article as:
Karaaslan Cigdem and Suzen Sibel, Antioxidant Properties of Melatonin and its Potential Action in Diseases, Current Topics in Medicinal Chemistry 2015; 15 (9) . https://dx.doi.org/10.2174/1568026615666150220120946
DOI https://dx.doi.org/10.2174/1568026615666150220120946 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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