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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients

Author(s): Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles and John H. Zhang

Volume 22, Issue 10, 2015

Page: [1302 - 1309] Pages: 8

DOI: 10.2174/0929867322666150209153606

Price: $65

Abstract

Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.

Keywords: Granulocyte-colony stimulating factor, neuroprotection, stroke, treatment.

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