Abstract
The optimization and kinetic of rosmarinic acid extraction from Orthosiphon stamineus were investigated in this study. In the preliminary study, the extractions were carried out to identify the optimal ethanol concentration. Then, the optimal ethanol concentration was used to optimize the extraction variables (solventto- solid loading ratio, temperature and time) by central composite design. The optimum conditions for the rosmarinic acid extraction were at the concentration of ethanol, 70% v/v; solvent-to-solid loading ratio, 9.14; extraction temperature, 56.53°C; and extraction time, 3 hours. Subsequently, this study used six proposed models to describe the kinetic of the rosmarinic acid extraction. Two-site kinetic model gave the best fit for the experimental data with the highest coefficient of determination, R2 (0.976) and the smallest values of root mean square error (RMSE) (1.522). The goodness of fit is due to the presence of the rate constants of both fast and slow released fractions in the model. Hence, two-site kinetic model is the most appropriate model to describe the rosmarinic acid extraction from O. stamineus in a reflux extraction system.
Keywords: Central Composite design, extraction, kinetic modeling, Orthosiphon stamineus, response surface methodology, rosmarinic acid.
Current Bioactive Compounds
Title:Optimization and Kinetic Modeling of Rosmarinic Acid Extraction from Orthosiphon stamineus
Volume: 10 Issue: 4
Author(s): Cher H. Lau, Lee S. Chua, Chew T. Lee and Ramlan Aziz
Affiliation:
Keywords: Central Composite design, extraction, kinetic modeling, Orthosiphon stamineus, response surface methodology, rosmarinic acid.
Abstract: The optimization and kinetic of rosmarinic acid extraction from Orthosiphon stamineus were investigated in this study. In the preliminary study, the extractions were carried out to identify the optimal ethanol concentration. Then, the optimal ethanol concentration was used to optimize the extraction variables (solventto- solid loading ratio, temperature and time) by central composite design. The optimum conditions for the rosmarinic acid extraction were at the concentration of ethanol, 70% v/v; solvent-to-solid loading ratio, 9.14; extraction temperature, 56.53°C; and extraction time, 3 hours. Subsequently, this study used six proposed models to describe the kinetic of the rosmarinic acid extraction. Two-site kinetic model gave the best fit for the experimental data with the highest coefficient of determination, R2 (0.976) and the smallest values of root mean square error (RMSE) (1.522). The goodness of fit is due to the presence of the rate constants of both fast and slow released fractions in the model. Hence, two-site kinetic model is the most appropriate model to describe the rosmarinic acid extraction from O. stamineus in a reflux extraction system.
Export Options
About this article
Cite this article as:
H. Lau Cher, S. Chua Lee, T. Lee Chew and Aziz Ramlan, Optimization and Kinetic Modeling of Rosmarinic Acid Extraction from Orthosiphon stamineus, Current Bioactive Compounds 2014; 10 (4) . https://dx.doi.org/10.2174/157340721004150206151452
DOI https://dx.doi.org/10.2174/157340721004150206151452 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Phytochemicals and Antioxidants: An Evaluation in Understanding the Human Lifeline
Current Nutrition & Food Science Neuromodulatory and Anti-Inflammatory Ingredient for Sensitive Skin: In Vitro Assessment
Inflammation & Allergy - Drug Targets (Discontinued) Sporadic Porphyria in a Patient with Stage II Melanoma Treated with Interferon α
Current Drug Safety Pharmacokinetic and Toxicological Characteristics of Tripterigium Glycosides and Their Derivatives
Current Drug Metabolism Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy
Current Pharmaceutical Design Derivatives of IL-16 to Modulate Airway Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Multiple Roles for Chemokines in the Pathogenesis of SIV Infection
Current HIV Research Current Concepts in the Diagnosis and Treatment of Type 1 and Type 2 Autoimmune Pancreatitis
Recent Patents on Inflammation & Allergy Drug Discovery Low Dose Aspirin, COX-Inhibition and Chemoprevention of Colorectal Cancer
Current Topics in Medicinal Chemistry Insight, Outcome and Recovery in Schizophrenia Spectrum Disorders: An Examination of their Paradoxical Relationship
Current Psychiatry Reviews Recent Patents on the Synthesis and Application of Silica Nanoparticles for Drug Delivery
Recent Patents on Biotechnology Neuropathic Pain: Is the End of Suffering Starting in the Gene Therapy?
Current Drug Targets Tissue Transglutaminase Expression During Neural Differentiation of Human Mesenchymal Stem Cells
CNS & Neurological Disorders - Drug Targets Benzimidazole Derivatives as Kinase Inhibitors
Current Medicinal Chemistry Macrolide Hybrid Compounds: Drug Discovery Opportunities in Anti- Infective and Anti-inflammatory Area
Current Topics in Medicinal Chemistry Therapeutic Implications of Gene Deletion of Ligands and Receptors of Members of TNF Superfamily
Medicinal Chemistry Reviews - Online (Discontinued) The Brain-Immune-Gut Triangle: Innate Immunity in Psychiatric and Neurological Disorders
Current Immunology Reviews (Discontinued) Synovial Inflammation Drives Structural Damage in Hand Osteoarthritis: a Narrative Literature Review
Current Rheumatology Reviews Editorial (Thematic Issue: Chemistry Bordering Biology: Highlights from the XXXIV Biennial Meeting of the RSEQ)
Current Topics in Medicinal Chemistry Nanocarriers in the Delivery of Hydroxychloroquine to the Respiratory System: An Alternative to COVID-19
Current Drug Delivery