Abstract
In the last several years, bone tumor related microRNA research showed an explosive growth. MicroRNA was found to have a high or low expression level in bone tumor tissue and some microRNAs proved to be the biomarker for poor prognosis. The majority of research was focused on osteosarcoma and Ewing sarcoma. Many tumor associated molecules, including oncogenes and tumor suppressor genes, were found to be the direct targets for microRNA, and enhanced microRNA may play the regulatory role in tumor development. In the bone tumor cell lines, overexpression of microRNA could promote or inhibit the tumor growth, migration, invasion, and metastasis, especially for osteosarcoma and Ewing sarcoma. Many key molecules proved important for tumor genesis were found directly binding to the related microRNA, and whose expression level was down regulated. This may provide a novel therapeutic target for bone tumor. Large scale clinical samples detection and high through-put microarray assay have demonstrated microRNA might be applied to predict and diagnose the bone tumor. MicroRNA in serum was also proved significant as a biomarker for bone tumor.
Keywords: Bone tumor, Ewing sarcoma, microRNA, osteosarcoma.
Current Signal Transduction Therapy
Title:MicroRNA and Bone Tumor: To Up Date
Volume: 9 Issue: 3
Author(s): Huichao Wang, Ruiqiang Zhang, Yudong Jia, Xiaodong Zhang, Yingjie Zhu, Ying Zhang, Xiantao Chen, Xiaoqiang Zhang, Litao Cai, Hanzheng Zhao, Wuyin Li and Youwen Liu
Affiliation:
Keywords: Bone tumor, Ewing sarcoma, microRNA, osteosarcoma.
Abstract: In the last several years, bone tumor related microRNA research showed an explosive growth. MicroRNA was found to have a high or low expression level in bone tumor tissue and some microRNAs proved to be the biomarker for poor prognosis. The majority of research was focused on osteosarcoma and Ewing sarcoma. Many tumor associated molecules, including oncogenes and tumor suppressor genes, were found to be the direct targets for microRNA, and enhanced microRNA may play the regulatory role in tumor development. In the bone tumor cell lines, overexpression of microRNA could promote or inhibit the tumor growth, migration, invasion, and metastasis, especially for osteosarcoma and Ewing sarcoma. Many key molecules proved important for tumor genesis were found directly binding to the related microRNA, and whose expression level was down regulated. This may provide a novel therapeutic target for bone tumor. Large scale clinical samples detection and high through-put microarray assay have demonstrated microRNA might be applied to predict and diagnose the bone tumor. MicroRNA in serum was also proved significant as a biomarker for bone tumor.
Export Options
About this article
Cite this article as:
Wang Huichao, Zhang Ruiqiang, Jia Yudong, Zhang Xiaodong, Zhu Yingjie, Zhang Ying, Chen Xiantao, Zhang Xiaoqiang, Cai Litao, Zhao Hanzheng, Li Wuyin and Liu Youwen, MicroRNA and Bone Tumor: To Up Date, Current Signal Transduction Therapy 2014; 9 (3) . https://dx.doi.org/10.2174/1574362410666150116235118
DOI https://dx.doi.org/10.2174/1574362410666150116235118 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Potential of Modulating Wnt Signaling Pathway Toward the Development of Bone Anabolic Agent
Current Molecular Pharmacology The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications
Current Pharmaceutical Design Promoters and Control Elements: Designing Expression Cassettes for Gene Therapy
Current Gene Therapy Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells
Current Drug Targets Prediction and Early Evaluation of Anticancer Therapy Response: From Imaging of Drug Efflux Pumps to Targeted Therapy Response
Current Medicinal Chemistry Viral Vectors in Cancer Immunotherapy: Which Vector for Which Strategy?
Current Gene Therapy Structure-Function Relationships of PEDF
Current Molecular Medicine Thymoquinone Anticancer Discovery: Possible Mechanisms
Current Drug Discovery Technologies From the Sea to Anticancer Therapy
Current Medicinal Chemistry Pharmacological Intervention of Cyclooxygenase-2 and 5-Lipoxygenase Pathways. Impact on Inflammation and Cancer
Current Pharmaceutical Design Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1<sup>®</sup> can Overcome Drug Resistance in Osteosarcoma
Current Cancer Drug Targets Utilization of Enzyme Inhibitors in Study of Mechanism Underlying apoA-I-mediated HDL Generation in Rat Brain Astrocytes
Current Enzyme Inhibition The Current and Future Therapies for Human Osteosarcoma
Current Cancer Therapy Reviews A Novel Lily-of-the-Valley Fragrance Contrast Agent for Magnetic Resonance and Fluorescence Imaging of Prostate Cancer Cells
Current Pharmaceutical Biotechnology Advances in Cancer Stem Cell Therapy: Targets and Treatments
Recent Patents on Regenerative Medicine Potential Role for High and Low Molecular Weight Tissue Transglutaminases in Transforming Mammalian Cell Properties
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The S100A8 and S100A9 Proteins are Attractive Targets to Modulate Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Cutting through the Complexities of mTOR for the Treatment of Stroke
Current Neurovascular Research A Comprehensive Insight Towards Pharmaceutical Aspects of Graphene Nanosheets
Current Pharmaceutical Biotechnology A hypothesis for the role of RECK in angiogenesis
Current Vascular Pharmacology