Abstract
Traumatic Spinal Cord Injuries (TSCI), due to their devastating nature, present several interventional challenges (extensive inflammation, axonal tethering, scar formation, neuronal degeneration and functional loss) that need to be addressed before even a slight neuronal recovery can be achieved. Recent post-TSCI investigational approaches include a combination of “support and therapeutic” strategies capable of providing localized delivery of therapeutic molecules along with specialized architecture to allow axonal growth and conformal repair. This review provides a brief overview of multifunctional therapeutic delivery strategies for effective neuroregeneration post-TSCI with special emphasis on intrathecal hydrogel-based injectable systems, chondroitinase ABC releasing matrices, micro/nano-sized particulate strategies, 3D-scaffold architectures, biopolymeric channeled bridges for directed neuronal growth, functionalized nerve conduits, nano- and micro-fibrous scaffolds and multicomponent combinatorial paradigms for localized delivery to spinal cord. In addition; a comprehensive account of most widely employed macromolecules and the related neuro-pharmacological, -anatomical, and -functionaloutcomes conferred by the abovementioned neural tissue engineering approaches is provided. Furthermore, the performance of individual delivery systems towards the enhancement of effectiveness, efficiency, and stability of therapeutic molecules and neurotrophic factors is discussed. In conclusion, it is suggested that a multifunctional combinatorial device assimilating the biomaterial, cellular, molecular, structural and functional aspects altogether is the best way forward for effective neuroregeneration post-TSCI.
Keywords: Spinal cord injury, hydrogels, scaffolds, multiple channel bridges, nerve conduits, fibrous architectures, neurotrophic factors, sustained release.
Current Pharmaceutical Design
Title:Multifunctional Therapeutic Delivery Strategies for Effective Neuro-Regeneration Following Traumatic Spinal Cord Injury
Volume: 21 Issue: 12
Author(s): Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Viness Pillay
Affiliation:
Keywords: Spinal cord injury, hydrogels, scaffolds, multiple channel bridges, nerve conduits, fibrous architectures, neurotrophic factors, sustained release.
Abstract: Traumatic Spinal Cord Injuries (TSCI), due to their devastating nature, present several interventional challenges (extensive inflammation, axonal tethering, scar formation, neuronal degeneration and functional loss) that need to be addressed before even a slight neuronal recovery can be achieved. Recent post-TSCI investigational approaches include a combination of “support and therapeutic” strategies capable of providing localized delivery of therapeutic molecules along with specialized architecture to allow axonal growth and conformal repair. This review provides a brief overview of multifunctional therapeutic delivery strategies for effective neuroregeneration post-TSCI with special emphasis on intrathecal hydrogel-based injectable systems, chondroitinase ABC releasing matrices, micro/nano-sized particulate strategies, 3D-scaffold architectures, biopolymeric channeled bridges for directed neuronal growth, functionalized nerve conduits, nano- and micro-fibrous scaffolds and multicomponent combinatorial paradigms for localized delivery to spinal cord. In addition; a comprehensive account of most widely employed macromolecules and the related neuro-pharmacological, -anatomical, and -functionaloutcomes conferred by the abovementioned neural tissue engineering approaches is provided. Furthermore, the performance of individual delivery systems towards the enhancement of effectiveness, efficiency, and stability of therapeutic molecules and neurotrophic factors is discussed. In conclusion, it is suggested that a multifunctional combinatorial device assimilating the biomaterial, cellular, molecular, structural and functional aspects altogether is the best way forward for effective neuroregeneration post-TSCI.
Export Options
About this article
Cite this article as:
Kumar Pradeep, Choonara E. Yahya, Modi Girish, Naidoo Dinesh and Pillay Viness, Multifunctional Therapeutic Delivery Strategies for Effective Neuro-Regeneration Following Traumatic Spinal Cord Injury, Current Pharmaceutical Design 2015; 21 (12) . https://dx.doi.org/10.2174/1381612821666150115152323
DOI https://dx.doi.org/10.2174/1381612821666150115152323 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Therapeutic Value of Adeno Associated Virus as a Gene Therapy Vector for Parkinson's Disease – A Focused Review
Current Gene Therapy Neuronal Generation from Somatic Stem Cells: Current Knowledge and Perspectives on the Treatment of Acquired and Degenerative Central Nervous System Disorders
Current Gene Therapy Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of Diabetes Mellitus in Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Adrenomedullin: Exciting New Horizons
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery How to Make a Non-Antigenic Protein (Auto) Antigenic: Molecular Complementarity Alters Antigen Processing and Activates Adaptive-Innate Immunity Synergy
Anti-Cancer Agents in Medicinal Chemistry The GABAergic System and the Gastrointestinal Physiopathology
Current Pharmaceutical Design Patent Annotations
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Neuroprotection by Association of Palmitoylethanolamide with Luteolin in Experimental Alzheimer’s Disease Models: The Control of Neuroinflammation
CNS & Neurological Disorders - Drug Targets Conantokins: Peptide Antagonists of NMDA Receptors
Current Medicinal Chemistry Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders
Mini-Reviews in Medicinal Chemistry Non-Neuronal Cell Modulation Relieves Neuropathic Pain: Efficacy of the Endogenous Lipid Palmitoylethanolamide
CNS & Neurological Disorders - Drug Targets Targeting Class IIa HDACs: Insights from Phenotypes and Inhibitors
Current Medicinal Chemistry Effectiveness of Post-Mortem Computed Tomography (PMCT) in Comparison with Conventional Autopsy: A Systematic Review
Current Medical Imaging Sympathetic Mechanisms of Hypoglycemic Counterregulation
Current Diabetes Reviews The Hypothalamic-Neurohypophyseal System: Current and Future Treatment of Vasopressin and Oxytocyn Related Disorders
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Natural Products Targeting Cancer Stem Cells: A Revisit
Current Medicinal Chemistry Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets The Influence of Inflammatory Cytokines on the Proliferation and Osteoblastic Differentiation of MSCs
Current Stem Cell Research & Therapy Single Amino Acid Repeats Connect Viruses to Neurodegeneration
Current Drug Discovery Technologies Impacting Neuronal and Vascular Cellular Signal Transduction through the Metabotropic Glutamate Receptor System
Medicinal Chemistry Reviews - Online (Discontinued)