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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

A P-Ligand-Free Nickel-Catalyzed Variation of the Hirao Reaction Under Microwave Conditions

Author(s): Erzsebet Jablonkai, Laszlo B. Balazs and Gyorgy Keglevich

Volume 19, Issue 2, 2015

Page: [197 - 202] Pages: 6

DOI: 10.2174/1385272819666150114235413

Abstract

The Hirao reaction, an important tool for the establishment of a P-C bond, was developed further by finding that the reaction of >P(O)H species, such as dialkyl phosphites, alkyl phenyl-H-phosphinates and diarylphosphine oxides with bromoarenes may be carried out in the presence of P-ligand-free NiCl2 as the catalyst. The scope and limitations of this “greener” approach was studied in detail.

Keywords: >P(O)H species, aryl bromides, Hirao reaction, microwave, Ni-catalyst, P-ligand-free.

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