A Facile and Efficient Synthesis of Spiro[indoline-3,5`-pyrido[2,3-d] pyrimidine] Derivatives via Microwave-assisted Multicomponent Reactions

Title:A Facile and Efficient Synthesis of Spiro[indoline-3,5`-pyrido[2,3-d] pyrimidine] Derivatives via Microwave-assisted Multicomponent Reactions

Volume: 12 Issue: 1

Author(s): Jing Wang, Jie Li, Hongzhi Liu, Zhou Xu and Songlei Zhu

Affiliation:

Keywords: spiro[indoline-3, 5`-pyrido[2, 3-d]pyrimidine], microwave, multicomponent reactions.

Abstract: A facile and efficient synthesis of spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine] derivatives by one-pot reactions of isatins, 2,6-diaminopyrimidin-4-one or 6-aminopyrimidine-2,4-dione and malononitrile under microwave irradiation conditions was investigated. This protocol has the virtue of short reaction time, high yields and easy work-up procedure.

Cite this article as:

Wang Jing, Li Jie, Liu Hongzhi, Xu Zhou and Zhu Songlei, A Facile and Efficient Synthesis of Spiro[indoline-3,5`-pyrido[2,3-d] pyrimidine] Derivatives via Microwave-assisted Multicomponent Reactions, Letters in Organic Chemistry 2015; 12 (1) . https://dx.doi.org/10.2174/157017861201150112124526