Design and Efficient Synthesis of Some Azole and Thiazole Systems Based 3-(1,3-Dioxoisoindolin-2-yl)-3-oxopropanenitrile

Title:Design and Efficient Synthesis of Some Azole and Thiazole Systems Based 3-(1,3-Dioxoisoindolin-2-yl)-3-oxopropanenitrile

Volume: 12 Issue: 3

Author(s): Islam Helmy El Aazab and Fawi Mohamed Abd El Latif

Affiliation:

Keywords: Azole, thiazole, phthalimide, pyrazole, enaminonitrile, 1, 3-dioxoisoindoline.

Abstract: A variety of pyrazoles, thiazoles, thiadiazoles, thiazolidines, azetidine, thiazolo[3,2-a]pyrimidine and pyrazolo[3,4-b]pyridine systems, based on 3-(1,3-dioxoisoindolin-2-yl)-3-oxopropanenitrile precursor are synthesized in good yields. The mechanistic aspect for the formation of the newly synthesized compounds is discussed and the structure of the synthesized compounds was established based on elemental analysis and spectral data.

Cite this article as:

El Aazab Helmy Islam and El Latif Mohamed Abd Fawi, Design and Efficient Synthesis of Some Azole and Thiazole Systems Based 3-(1,3-Dioxoisoindolin-2-yl)-3-oxopropanenitrile, Letters in Organic Chemistry 2015; 12 (3) . https://dx.doi.org/10.2174/1570178612666150108001531