Abstract
The derivatives of quinolinone and triazole exhibit antitumor, antiplatelet, antidepressant, and anticonvulsant properties in diverse experimental systems. In the past decades, we have developed increasingly potent anticonvulsant agents by the structural modification of compounds derived from 3,4-DHQLO, triazole, and their analogs. Herein, we report the design and synthesis of a new series of 3,4-DHQLO and triazole and their derivatives; their anticonvulsant activity was evaluated. Moreover, we also reviewed the anticonvulsant activity of 3,4-DHQLO and triazole and their derivatives and new approaches.
Keywords: Anticonvulsant activity, 3, 4-DHQLO, Synthesis, Structure-activity relationship, Triazole.
Mini-Reviews in Medicinal Chemistry
Title:3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects
Volume: 16 Issue: 4
Author(s): Li-Ping Guan and Zhe-Shan Quan
Affiliation:
Keywords: Anticonvulsant activity, 3, 4-DHQLO, Synthesis, Structure-activity relationship, Triazole.
Abstract: The derivatives of quinolinone and triazole exhibit antitumor, antiplatelet, antidepressant, and anticonvulsant properties in diverse experimental systems. In the past decades, we have developed increasingly potent anticonvulsant agents by the structural modification of compounds derived from 3,4-DHQLO, triazole, and their analogs. Herein, we report the design and synthesis of a new series of 3,4-DHQLO and triazole and their derivatives; their anticonvulsant activity was evaluated. Moreover, we also reviewed the anticonvulsant activity of 3,4-DHQLO and triazole and their derivatives and new approaches.
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Cite this article as:
Guan Li-Ping and Quan Zhe-Shan, 3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects, Mini-Reviews in Medicinal Chemistry 2016; 16 (4) . https://dx.doi.org/10.2174/1389557515666150101100909
DOI https://dx.doi.org/10.2174/1389557515666150101100909 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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