Abstract
Bacterial biofilms are highly organized surface-associated communities of bacteria encased within an extracellular matrix produced by themselves, capable of growing in connection with different biological or inert surfaces such as artificial joints or catheters. Biofilms are commonly associated with many health problems, such as endocarditis, otitis media, periodontitis, prostatitis, and urinary tract infections. Several bacteria, such as Escherichia coli, Staphylococcus aureus, Streptococcus mutans, and Pseudomonas aeruginosa, or fungal pathogen as Candida albicans, can form biofilms in the body tissues, leading to different infections. The inherently defensive character of the biofilm is demonstrated by enhanced persistence of bacteria grown in the sessile mode respect to bacteria grown planktonically. This makes most biofilm- associated infections difficult to eradicate, thus contributing to disease chronicity. Since natural products provide a diverse array of chemical structures and possess a wide variety of biological properties, natural resources are worldwide exploited in the search of new pharmaceuticals. In this context bioactive secondary metabolites from natural sources, useful for the new antimicrobial and anti-biofilm drugs, are of interest. In this review, the role of small molecules from plants and marine organisms in inhibiting and/or dispersing bacterial biofilms is discussed, as well as the approaches that have been applied to the discovery of lead small molecules that mediate biofilm development. Molecules inhibiting the formation of biofilm may have therapeutic potential. Several candidates, as halogenated furanones, 2-amminoimidazole alkaloids and flavonoids have been already isolated and characterized from many plants and from marine organisms.
Keywords: Biofilm, Candida albicans, natural compounds, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans.
Mini-Reviews in Medicinal Chemistry
Title:Recent Advances in Natural Product-Based Anti-Biofilm Approaches to Control Infections
Volume: 14 Issue: 14
Author(s): Elisabetta Buommino, Monica Scognamiglio, Giovanna Donnarumma, Antonio Fiorentino and Brigida D’Abrosca
Affiliation:
Keywords: Biofilm, Candida albicans, natural compounds, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans.
Abstract: Bacterial biofilms are highly organized surface-associated communities of bacteria encased within an extracellular matrix produced by themselves, capable of growing in connection with different biological or inert surfaces such as artificial joints or catheters. Biofilms are commonly associated with many health problems, such as endocarditis, otitis media, periodontitis, prostatitis, and urinary tract infections. Several bacteria, such as Escherichia coli, Staphylococcus aureus, Streptococcus mutans, and Pseudomonas aeruginosa, or fungal pathogen as Candida albicans, can form biofilms in the body tissues, leading to different infections. The inherently defensive character of the biofilm is demonstrated by enhanced persistence of bacteria grown in the sessile mode respect to bacteria grown planktonically. This makes most biofilm- associated infections difficult to eradicate, thus contributing to disease chronicity. Since natural products provide a diverse array of chemical structures and possess a wide variety of biological properties, natural resources are worldwide exploited in the search of new pharmaceuticals. In this context bioactive secondary metabolites from natural sources, useful for the new antimicrobial and anti-biofilm drugs, are of interest. In this review, the role of small molecules from plants and marine organisms in inhibiting and/or dispersing bacterial biofilms is discussed, as well as the approaches that have been applied to the discovery of lead small molecules that mediate biofilm development. Molecules inhibiting the formation of biofilm may have therapeutic potential. Several candidates, as halogenated furanones, 2-amminoimidazole alkaloids and flavonoids have been already isolated and characterized from many plants and from marine organisms.
Export Options
About this article
Cite this article as:
Buommino Elisabetta, Scognamiglio Monica, Donnarumma Giovanna, Fiorentino Antonio and D’Abrosca Brigida, Recent Advances in Natural Product-Based Anti-Biofilm Approaches to Control Infections, Mini-Reviews in Medicinal Chemistry 2014; 14 (14) . https://dx.doi.org/10.2174/1389557515666150101095853
DOI https://dx.doi.org/10.2174/1389557515666150101095853 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The First Years of Linezolid Experience in Clinical Practice: A Balance and Future Implications
Anti-Infective Agents in Medicinal Chemistry Therapeutic Utilities of Pediatric Cardiac Catheterization
Current Cardiology Reviews Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
Current Molecular Medicine Ophthalmological and Otological Manifestations in the Antiphospholipid Syndrome
Current Rheumatology Reviews Emergence of Methicillin-Resistant Staphylococcus aureus (MRSA) as a Public-Health Threat and Future Directions of Antibiotic Therapy for MRSA Infections
Anti-Infective Agents Mechanisms of β -lactam Resistance Among Pseudomonas aeruginosa
Current Pharmaceutical Design Cardiac Tumors: Clinical Perspective and Therapeutic Considerations
Current Drug Targets Secondary Prevention of Ischemic Stroke
Current Drug Targets Hallmarks in the Therapeutic Approach of Aortic Aneurysms: The Main Contributors
Current Pharmaceutical Design Heart Failure in Acute Ischemic Stroke
Current Cardiology Reviews Editorial [Hot topic: Infective Endocarditis (Guest Editor: Ioannis Starakis)]
Infectious Disorders - Drug Targets Torsades de Pointes in Patients with Polymyalgia Rheumatica
Current Pharmaceutical Design Potential Antibacterial Activity of Yemeni Sidr Honey Against <i>Pseudomonas aeruginosa</i> and <i>Streptococcus pyogenes</i>
Anti-Infective Agents The Relationship Between HIV Infection and Cardiovascular Disease
Current Cardiology Reviews Cardiovascular Disease in Antiphospholipid Syndrome
Current Vascular Pharmacology New Developments in Antimicrobial Use in Sepsis
Current Pharmaceutical Design Bacterial Protein Microarrays for Diagnosis of Infectious Diseases
Current Immunology Reviews (Discontinued) Myocardial Infarction in Systemic Lupus Erythematosus – the Sex-Specific Risk Profile
Current Pharmaceutical Design Antimicrobial Peptides as Anti-biofilm Agents in Medical Implants
Current Topics in Medicinal Chemistry Aspirin Resistance in Cardiovascular Disease: Pathogenesis, Diagnosis and Clinical Impact
Current Pharmaceutical Design