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ISSN (Online): 2215-0846
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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846
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Editor(s): Liang Qiao
Co-Editor(s): Yumin Li, Xiang Yan and Jacob George
eISBN: 978-1-60805-072-7, 2012
Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. It should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.
Editor(s): Paulo Renato Zuquim Antas
Co-Editor(s): Dilvani Oliveira Santos, Roberta Olmo Pinheiro and Theolis Barbosa
eISBN: 978-1-60805-302-5, 2012
One of the most extraordinary characteristics of Mycobacterium tuberculosis infection is its capacity to remain within the host's tissues for a long period of time. There is an enormous reservoir of persons latently infected with tuberculosis (LTBI) estimated at about a third of the world's population. From this reservoir arise about 10 million new cases of active TB and more than two million deaths occur annually. Current Diagnosis of Infant Tuberculosis Infection covers problems concerning the diagnosis of LTBI, giving an overview of commercially available options and, unlike most reviews on this subject, also points out some tools currently under development. The Ebook provides comprehensive understandable, practice-oriented information on this subject, while keeping frontier research developments in consideration. It serves as an update to readers from universities to the research center and hospital staff - as well as a guide for helping clinicians to improve their diagnostic skills regarding TB infections in an endemic country (such as Brazil).
Editor(s): Estela Maria Novak and Eduardo Magalhães Rego
eISBN: 978-1-60805-259-2, 2012
The number of new discoveries related to diagnostics and therapeutics of hematological cancer is significant. These have resulted in continuous progress in fundamental knowledge about molecular and cellular mechanisms in hematological neoplasia. Physiopathogenesis of Hematological Cancer presents a concise overview of the cellular and molecular biology of myelo- and Lymphoproliferative disorders. The expert reviews presented within this e-book are also accompanied by bibliographic references for relevant scientific literature. This book should prove to be a valuable reference tool for both medical graduate and postgraduates in the field of oncology.
Editor(s): Margareta Kristenson, Peter Garvin and Ulf Lundberg
eISBN: 978-1-60805-342-1, 2012
This e-book is based on a critical evaluation of existing literature on salivary cortisol, aiming to evaluate the utility of salivary cortisol as a biomarker in various settings. It focuses on how different ways of evaluating levels of salivary cortisol may have an impact on the interpretation of cortisol measurements in various contexts.
This e-book focuses on salivary cortisol in relation to the following topics: psychosocial work environment (effort reward imbalance and job demand vs control model), psychosocial resources (mastery, perceived control, sense of coherence), psychosocial risk factors (perceived stress, depression, vital exhaustion, burn-out), sleep quality, biological markers (bodily factors, cardiovascular risk factors, inflammation and metabolism) and somatic outcome.
This ebook should serve as a reference for studies planned to adopt cortisol as an assessment tool.
Editor(s): Toshiyuki Hata
Co-Editor(s): Asim Kurjak and Shiro Kozuma
eISBN: 978-1-60805-019-2, 2009
Editor(s): Javier Camacho
eISBN: 978-1-60805-016-1, 2012
Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecular targets and rational drug design on this molecular basis should help in discovering early cancer biomarkers as well as novel therapeutic drugs.
This book describes various cancer topics on a molecular level and integrates information on the relationship between causes of cancer, cancer cell biology, metastasis, cancer prevention and drug design. This book should prove to be an extraordinary reference text for students, physicians and oncologists.
Editor(s): Pierre Delanaye
eISBN: 978-1-60805-333-9, 2012
Clinical chemistry is a science that requires specific knowledge and teaching. The e-book covers several topics in clinical nephrology. Patients suffering from severe chronic kidney disease may be quasi asymptomatic. This lack of overt symptomatology suggests that clinical laboratory tests are of the highest importance. Clinicians treating patients and clinical biologists operating in laboratories are often far apart from each other. They have a lot of things to share and to learn from each other. This e-book bridges the gap between these two groups of health professionals.
Editor(s): Ichiro Shimizu
eISBN: 978-1-60805-293-6, 2012
Liver cancer, cirrhosis and nonalcoholic fatty liver disease are observed predominately in men. Being male or female is believed to be an important human variable that affects health and liver disease throughout the life span. However, few works have been published on the biological mechanisms underlying gender specific differences in liver disease. Several mechanisms underlying sex-associated differences of progression of liver disease are demonstrated in this e-book based on biological factors as estrogen and hepatic iron stores. Readers will gain a better understanding of the pathogenesis of these sex-associated differences in liver disease and on how to design healthcare for liver disease more effectively for individuals belonging to both genders. The e-book should be a useful reference on gender specific medicine for counselors and clinicians as well as for patients with chronic liver disease.
Author(s): Bashir M. Matata and Maqsood M. Elahi
eISBN: 978-1-60805-286-8, 2011
This e-book discusses the molecular relationship between biological systems and risk factors for in-utero oxidative insults, maternal health and the impact on fetus at different critical developmental time windows (prenatal or even postnatal). Plausibly, prenatal and early postnatal periods are the most critical “windows” to oxidative stress programming insults. Pro-oxidative stress is a common feature of many conditions associated with adverse fetal growth and/or preterm birth, such as pre-eclampsia, diabetes, smoking, malnutrition or excessive nutrition, infection or inflammation. Oxidative stress insults may be directly linked to or associated with many genetic, nutritional and environmental risk factors that contribute to risks of adverse fetal growth or preterm birth. This e-book should be a valuable reference for medical researchers and working professionals interested in congenital defects.
Editor(s): Klaus Podar and Kenneth C. Anderson
eISBN: 978-1-60805-297-4, 2012
Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced disruption of the bone marrow homeostasis between the highly organized cellular and extracellular compartments supports MM cell proliferation, survival, migration, and drug resistance via activation of various signaling pathways. Based on this knowledge, the prototypic drugs thalidomide, bortezomib, and lenalidomide, which target both MM cells and the bone marrow microenvironment, have already fundamentally changed treatment options of this disease. Indeed, their benefit is now not only shown in relapsed and refractory disease but they also improve overall response, duration of response, and progression-free and overall survival when used as part of first-line regimens. However, despite new insights into MM pathogenesis and exciting derived therapeutic advances, MM still remains incurable. Ongoing studies are therefore aiming to further delineate mechanisms of MM pathogenesis within the bone marrow to identify novel agents with enhanced cytotoxicity and decreased drug resistance to improve patient outcome.
Multiple Myeloma - A New Era of Treatment Strategies is devoted to contributions from eminent scientists providing readers with comprehensive accounts of the most recent developments in the field of MM research. It addresses the interests of scientists and clinical investigators in MM research as well as other fields of oncology, in which the microenvironment is believed to play an important role.
Editor(s): Matt T. Bianchi, Verne S. Caviness and Sydney S. Cash
eISBN: 978-1-60805-017-8, 2012
This book covers novel approaches using networks and oscillations and it will serve as a catalyst for translating these exciting advancements into the clinical arena. This collection of articles aims to accelerate the widespread clinical translation of network approaches by providing practical information accessible to clinicians in neurology and psychiatry - fields that are uniquely poised to implement these developments in clinical treatment of brain diseases. It should be a useful resource for researchers and working professionals in neurological and psychiatric academic centers.
Editor(s): Liliana Olmos, Carlos Alberto Torres and Rich Van Heertum
eISBN: 978-1-60805-268-4, 2011
ISBN: 978-1-60805-336-0 ISSN: 2211-727X (Print)
Globalization has emerged as one of the key social, political and economic forces of the twenty-first century, challenging national borders, long established institutions of governance and cultural norms and behaviors around the world. Yet how has it affected education? The series explores the complex and multivariate ways in which changing global paradigms have influenced education, democracy and citizenship from Latin America, Europe and Africa to Asia, the Middle East and North America. It seeks to unearth how these changes have manifest themselves in daily classroom experiences for teachers and administrators the world over and how recent events might influence future change.