Abstract
MicroRNAs (miRNA) are small (~22 nucleotide] non-coding RNA molecules originally characterised as nonsense or junk DNA. Emerging research suggests that these molecules have diverse regulatory roles in an array of molecular, cellular and physiological processes. MiRNAs are versatile and highly stable molecules, therefore, they are able to exist as intracellular or extracellular miRNAs. The purpose of this paper is to review the function and role of miRNAs in the intracellular space with specific focus on the interactions between miRNAs and organelles such as the mitochondria and the rough endoplasmic reticulum. Understanding the role of miRNAs in the intracellular space may be vital in understanding the mechanism of certain diseases.
Keywords: Cancer, endoplasmic reticulum, miRNA, mitochondria, organelles, P-bodies.
MicroRNA
Title:MicroRNAs in the Intracellular Space, Regulation of Organelle Specific Pathways in Health and Disease
Volume: 3 Issue: 2
Author(s): Thao T. Nguyen, Ekua W. Brenu, Don R. Staines and Sonya M. Marshall-Gradisnik
Affiliation:
Keywords: Cancer, endoplasmic reticulum, miRNA, mitochondria, organelles, P-bodies.
Abstract: MicroRNAs (miRNA) are small (~22 nucleotide] non-coding RNA molecules originally characterised as nonsense or junk DNA. Emerging research suggests that these molecules have diverse regulatory roles in an array of molecular, cellular and physiological processes. MiRNAs are versatile and highly stable molecules, therefore, they are able to exist as intracellular or extracellular miRNAs. The purpose of this paper is to review the function and role of miRNAs in the intracellular space with specific focus on the interactions between miRNAs and organelles such as the mitochondria and the rough endoplasmic reticulum. Understanding the role of miRNAs in the intracellular space may be vital in understanding the mechanism of certain diseases.
Export Options
About this article
Cite this article as:
Nguyen T. Thao, Brenu W. Ekua, Staines R. Don and Marshall-Gradisnik M. Sonya, MicroRNAs in the Intracellular Space, Regulation of Organelle Specific Pathways in Health and Disease, MicroRNA 2014; 3 (2) . https://dx.doi.org/10.2174/2211536604666141218154252
DOI https://dx.doi.org/10.2174/2211536604666141218154252 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hypersensitivity Reactions to Ophthalmic Products
Current Pharmaceutical Design Preservation Solutions for Solid Organ Transplantation
Mini-Reviews in Medicinal Chemistry Vasopressin in Health and Disease with a Focus on Affective Disorders
Central Nervous System Agents in Medicinal Chemistry Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology
Current Drug Targets Supplementation of Creatine and Ribose Prevents Apoptosis and Right Ventricle Hypertrophy in Hypoxic Hearts
Current Pharmaceutical Design Regenerative Therapies for Improving Myocardial Perfusion in Patients with Cardiovascular Disease: Failure to Meet Expectations but Optimism for the Future
Current Vascular Pharmacology Cardiomyocyte-Specific TβR2 Knockout Mice are More Susceptible to Cardiac Hypertrophy Induced by Adrenergic Agonist Stimulation
Current Molecular Medicine The Future of Collateral Artery Research
Current Cardiology Reviews Development of Pin1 Inhibitors and their Potential as Therapeutic Agents
Current Medicinal Chemistry Cardiovascular Effects of Liraglutide
Current Hypertension Reviews The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part III: Specific Management and Surgical Aspects
Current Cardiology Reviews Editorial: The Interplay between TSH and Lipids. What Should Clinicians Know?
Current Vascular Pharmacology Statins and Protein Prenylation in Cancer Cell Biology and Therapy
Anti-Cancer Agents in Medicinal Chemistry The Role of Calcium Handling Mechanisms in Reperfusion Injury
Current Pharmaceutical Design Circulating Endothelial Progenitor Cells Characterization, Function and Relationship with Cardiovascular Risk Factors
Current Pharmaceutical Design Intracellular Protozoan Parasites of Humans: The Role of Molecular Chaperones in Development and Pathogenesis
Protein & Peptide Letters Sinus Node If Channel Inhibition – A New Therapeutic Approach to Heart Rate Lowering
Current Drug Therapy Mechanisms of Chondrocyte Survival and Matrix Synthesis During Hypoxia
Current Rheumatology Reviews Integrins in Bone Metastasis Formation and Potential Therapeutic Implications
Current Cancer Drug Targets Fluoride Interactions: From Molecules to Disease
Current Signal Transduction Therapy