Abstract
In this paper, we report a rapid and facile synthesis of a series of some dihydropyrimidinone derivatives 4(a-e) and 5(a-e) under microwave radiation. All the synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR and elemental analyses. The compounds were screened for in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against gram positive and gram negative strains of bacteria. This pharmacological assessment data revealed that compounds 4c and 5c showed good anti-inflammatory activity. Besides, compounds 4a, 4c, 5b, 5c and 5e gave excellent results for the anti-bacterial activity evaluation against the selected strains of bacteria.
Keywords: Anti-bacterial, anti-inflammatory, chloroquinoline, dihydropyrimidinone, 1, 3, 4-oxadiazole, pyrazolone.
Current Microwave Chemistry
Title:Facile Microwave-Assisted Synthesis and Pharmacological Appraisal of Bioactive Dihydropyrimidinone Derivatives
Volume: 2 Issue: 2
Author(s): Ambareen Shaikh and Jyotsna S. Meshram
Affiliation:
Keywords: Anti-bacterial, anti-inflammatory, chloroquinoline, dihydropyrimidinone, 1, 3, 4-oxadiazole, pyrazolone.
Abstract: In this paper, we report a rapid and facile synthesis of a series of some dihydropyrimidinone derivatives 4(a-e) and 5(a-e) under microwave radiation. All the synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR and elemental analyses. The compounds were screened for in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against gram positive and gram negative strains of bacteria. This pharmacological assessment data revealed that compounds 4c and 5c showed good anti-inflammatory activity. Besides, compounds 4a, 4c, 5b, 5c and 5e gave excellent results for the anti-bacterial activity evaluation against the selected strains of bacteria.
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Cite this article as:
Shaikh Ambareen and S. Meshram Jyotsna, Facile Microwave-Assisted Synthesis and Pharmacological Appraisal of Bioactive Dihydropyrimidinone Derivatives, Current Microwave Chemistry 2015; 2 (2) . https://dx.doi.org/10.2174/2213335602666141217222008
DOI https://dx.doi.org/10.2174/2213335602666141217222008 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
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