FeCl₃/Ultrasound Mediated Reaction of 2-aminothiophenol with Aldehydes in Water: Synthesis of 2-substituted Benzothiazoles of Pharmacological Interest

Title:FeCl₃/Ultrasound Mediated Reaction of 2-aminothiophenol with Aldehydes in Water: Synthesis of 2-substituted Benzothiazoles of Pharmacological Interest

Volume: 12 Issue: 6

Author(s): Ponasanapalli Tirumala Venkata Ankayya Srinivas, Sallagundla Bhavani, Dandela Rambabu, Mandava Venkata Basaveswara Rao, Ravikumar Kapavarapu and Manojit Pal

Affiliation:

Keywords: Benzothiazole, FeCl₃, ultrasound, water, PDE4.

Abstract: We report a FeCl₃•6H2O mediated green and rapid access to benzothiazole derivatives having a substituent at C-2 via the condensation of 2-aminothiophenol with various aldehydes under ultrasound irradiation and air. The reaction progressed well in water affording the expected products in good yields. Two of these compounds known to be potent anticancer agents showed good interactions with PDE4B in silico and inhibited this enzyme when tested in vitro.

Cite this article as:

Tirumala Venkata Ankayya Srinivas Ponasanapalli, Bhavani Sallagundla, Rambabu Dandela, Venkata Basaveswara Rao Mandava, Kapavarapu Ravikumar and Pal Manojit, FeCl₃/Ultrasound Mediated Reaction of 2-aminothiophenol with Aldehydes in Water: Synthesis of 2-substituted Benzothiazoles of Pharmacological Interest, Letters in Drug Design & Discovery 2015; 12 (6) . https://dx.doi.org/10.2174/1570180812666141216211045