Abstract
Nandrolone is included in the class II of anabolic androgenic steroids (AAS) which is composed of 19-nor-testosterone-derivates. In general, AAS is a broad and rapidly increasing group of synthetic androgens used both clinically and illicitly. AAS in general and nandrolone decanoate (ND) in particular have been associated with several behavioral disorders. The purpose of this review is to summarize the literature concerning studies dealing with ND exposure on animal models, mostly rats that mimic human abuse systems (i.e. supraphysiological doses). We have focused in particular on researches that have investigated how ND alters the function and expression of neuronal signaling molecules that underlie behavior, anxiety, aggression, learning and memory, reproductive behaviors, locomotion and reward.
Keywords: Nandrolone decanoate (ND), Anabolic androgenic steroids (AAS), neurological effects, anxiety, aggression, learning and memory.
Current Neuropharmacology
Title:The Impact of Nandrolone Decanoate on the Central Nervous System
Volume: 13 Issue: 1
Author(s): Francesco P. Busardo, Paola Frati, Mariantonia Di Sanzo, Simona Napoletano, Enrica Pinchi, Simona Zaami and Vittorio Fineschi
Affiliation:
Keywords: Nandrolone decanoate (ND), Anabolic androgenic steroids (AAS), neurological effects, anxiety, aggression, learning and memory.
Abstract: Nandrolone is included in the class II of anabolic androgenic steroids (AAS) which is composed of 19-nor-testosterone-derivates. In general, AAS is a broad and rapidly increasing group of synthetic androgens used both clinically and illicitly. AAS in general and nandrolone decanoate (ND) in particular have been associated with several behavioral disorders. The purpose of this review is to summarize the literature concerning studies dealing with ND exposure on animal models, mostly rats that mimic human abuse systems (i.e. supraphysiological doses). We have focused in particular on researches that have investigated how ND alters the function and expression of neuronal signaling molecules that underlie behavior, anxiety, aggression, learning and memory, reproductive behaviors, locomotion and reward.
Export Options
About this article
Cite this article as:
Busardo P. Francesco, Frati Paola, Di Sanzo Mariantonia, Napoletano Simona, Pinchi Enrica, Zaami Simona and Fineschi Vittorio, The Impact of Nandrolone Decanoate on the Central Nervous System, Current Neuropharmacology 2015; 13 (1) . https://dx.doi.org/10.2174/1570159X13666141210225822
DOI https://dx.doi.org/10.2174/1570159X13666141210225822 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Management of the Infected Diabetic Foot
Current Diabetes Reviews The Effect of Statins on Postprandial Lipemia
Current Drug Targets Astrocytes and Inflammasome: A Possible Crosstalk in Neurological Diseases
Current Medicinal Chemistry Physiological Effect and Therapeutic Application of Alpha Lipoic Acid
Current Medicinal Chemistry Milk Thistle: A Future Potential Anti-Osteoporotic and Fracture Healing Agent
Current Drug Targets Editorial (Novel Therapies and Botanical and Mechanical Approaches for Management of Cardiovascular Disease)
Recent Patents on Cardiovascular Drug Discovery Molecular Mechanisms Involved in the Aging of the T-cell Immune Response
Current Genomics Gene Therapy in Disorders of Lipoprotein Metabolism
Current Gene Therapy Development and Clinical use of Prasugrel and Ticagrelor
Current Pharmaceutical Design Stroke Prevention: From Available Antiplatelet Drugs to Novel Molecular Targets
Current Drug Targets Therapeutic Potential of N-Acetylcysteine for Wound Healing, Acute Bronchiolitis, and Congenital Heart Defects
Current Drug Metabolism Polymorphisms in Methotrexate Pathways: What Is Clinically Relevant, What Is Not, and What Is Promising
Current Drug Metabolism Resveratrol and Ischemic Preconditioning in the Brain
Current Medicinal Chemistry Dry Age-Related Macular Degeneration: Recent Progress of Therapeutic approaches
Current Molecular Pharmacology Nitric Oxide and Dietary Factors: Part II Cholesterol, Fat, Amino Acids,Proteins and Carbohydrate
Vascular Disease Prevention (Discontinued) Placental Hypoxia Developed During Preeclampsia Induces Telocytes Apoptosis in Chorionic Villi Affecting The Maternal-Fetus Metabolic Exchange
Current Stem Cell Research & Therapy Hypertension in Obstructive Sleep Apnoea
Vascular Disease Prevention (Discontinued) Role of Iodine, Selenium and Other Micronutrients in Thyroid Function and Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Statins in Stroke Prevention: Present and Future
Current Pharmaceutical Design Anti-hyperglycemic Potential of Natural Products
Mini-Reviews in Medicinal Chemistry