Abstract
The objective of this paper is to review the evidence testing the possible benefit of vitamin D replacement on diabetes control and complications.
Type 2 diabetes mellitus (DM 2) has become a significant global health care problem and its reported incidence is increasing at an alarming rate. Despite the improvement in therapy and development of new drugs, treatment is still not optimal especially with the associated adverse effects of most of the available drugs. New efforts are shifted toward disease prevention and a search for safer drugs. New mounting evidence is associating low vitamin D to diabetes mellitus and as such many studies were conducted to test the effect of vitamin D replacement on incidence of diabetes, diabetes control as well as diabetes complications.
Although these studies present several limitations, vitamin D replacement seems to have beneficial effect on all aspects of diabetes: incidence, control and complications. Further longer term and more powered controlled trials are necessary to draw firmer conclusions on this beneficial role of vitamin D treatment on DM.
Keywords: 25 hydroxy vitamin D, type 2 diabetes mellitus, vitamin D replacement, 25 hydroxy vitamin D deficiency, diabetes control, diabetes complications.
Current Diabetes Reviews
Title:Vitamin D Replacement and Type 2 Diabetes Mellitus
Volume: 11 Issue: 1
Author(s): Claire. M. Issa, Mira S. Zantout and Sami T. Azar
Affiliation:
Keywords: 25 hydroxy vitamin D, type 2 diabetes mellitus, vitamin D replacement, 25 hydroxy vitamin D deficiency, diabetes control, diabetes complications.
Abstract: The objective of this paper is to review the evidence testing the possible benefit of vitamin D replacement on diabetes control and complications.
Type 2 diabetes mellitus (DM 2) has become a significant global health care problem and its reported incidence is increasing at an alarming rate. Despite the improvement in therapy and development of new drugs, treatment is still not optimal especially with the associated adverse effects of most of the available drugs. New efforts are shifted toward disease prevention and a search for safer drugs. New mounting evidence is associating low vitamin D to diabetes mellitus and as such many studies were conducted to test the effect of vitamin D replacement on incidence of diabetes, diabetes control as well as diabetes complications.
Although these studies present several limitations, vitamin D replacement seems to have beneficial effect on all aspects of diabetes: incidence, control and complications. Further longer term and more powered controlled trials are necessary to draw firmer conclusions on this beneficial role of vitamin D treatment on DM.
Export Options
About this article
Cite this article as:
M. Issa Claire., S. Zantout Mira and T. Azar Sami, Vitamin D Replacement and Type 2 Diabetes Mellitus, Current Diabetes Reviews 2015; 11 (1) . https://dx.doi.org/10.2174/1573399811666141210153503
DOI https://dx.doi.org/10.2174/1573399811666141210153503 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Quality of Life of Thalassemic Patients: The Role of Endocrine Defect
Compensation
Endocrine, Metabolic & Immune Disorders - Drug Targets Detrimental Effects of Hyperglycemia in Acute Coronary Syndromes: from Pathophysiological Mechanisms to Therapeutic Strategies
Mini-Reviews in Medicinal Chemistry Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy
Current Medicinal Chemistry Regulation of Neurogenesis and Gliogenesis by Stress and Antidepressant Treatment
CNS & Neurological Disorders - Drug Targets Application of NMR Metabolomics to Search for Human Disease Biomarkers
Combinatorial Chemistry & High Throughput Screening Nonfasting Hyperlipidemia and Cardiovascular Disease
Current Drug Targets Recent Studies of Aldose Reductase Enzyme Inhibition for Diabetic Complications
Current Medicinal Chemistry Sorbitol Dehydrogenase: Structure, Function and Ligand Design
Current Medicinal Chemistry Reactive Oxygen Species and Antioxidants in the Pathophysiology of Cardiovascular Disease: Does the Actual Knowledge Justify a Clinical Approach?
Current Vascular Pharmacology Potential Application of Non-flavonoid Phenolics in Diabetes: Antiinflammatory Effects
Current Medicinal Chemistry Effects of ACE-Inhibitors and Angiotensin Receptor Blockers on Inflammation
Current Pharmaceutical Design D-amino Acids as Novel Blood-based Biomarkers
Current Medicinal Chemistry Toll-like Receptors and Diabetes Complications: Recent Advances
Current Diabetes Reviews Biological Markers of Alzheimers Disease and Mild Cognitive Impairment
Current Alzheimer Research Mitochondrial Disturbances, Tryptophan Metabolites and Neurodegeneration: Medicinal Chemistry Aspects
Current Medicinal Chemistry Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets
Current Medicinal Chemistry Estrogen and Cytokines Production - The Possible Cause of Gender Differences in Neurological Diseases
Current Pharmaceutical Design The Extra-Hematopoietic Role of Erythropoietin in Diabetes Mellitus
Current Diabetes Reviews Pathophysiology of Diabetic Secondary Complication and their Management
Current Diabetes Reviews Rheumatological Manifestations in Diabetes Mellitus
Current Diabetes Reviews