Abstract
Despite multiple sclerosis (MS) represents one of the most fascinating mystery of modern medicine due to its unknown etiology and the incomplete knowledge of a clear mechanism of pathogenesis, progress against this disease has made giant leaps. Current management of MS takes advantage of many disease- modifying therapeutics of anti-inflammatory and immunomodulatory nature, whose primary aims are halting immune responses during attacks, preventing new attacks and avoiding disability. In this review, a synopsis on effective therapies targeting both immune-mediated responses and neurodegenerative processes is appointed. Oxidative stress has been also implicated in both the inflammatory and neurodegenerative pathological mechanisms underlying MS. The role of redox metabolism in MS is thus also reported, with particular focus on the latest improvements in the identification of oxidative stress as a potential new therapeutic target.
Keywords: Inflammation, Multiple sclerosis, Neurodegeneration, Oxidative stress, Remyelination, Therapeutics.
Current Topics in Medicinal Chemistry
Title:Novel Targets in Multiple Sclerosis: To Oxidative Stress and Beyond
Volume: 14 Issue: 22
Author(s): Valerio Chiurchiu
Affiliation:
Keywords: Inflammation, Multiple sclerosis, Neurodegeneration, Oxidative stress, Remyelination, Therapeutics.
Abstract: Despite multiple sclerosis (MS) represents one of the most fascinating mystery of modern medicine due to its unknown etiology and the incomplete knowledge of a clear mechanism of pathogenesis, progress against this disease has made giant leaps. Current management of MS takes advantage of many disease- modifying therapeutics of anti-inflammatory and immunomodulatory nature, whose primary aims are halting immune responses during attacks, preventing new attacks and avoiding disability. In this review, a synopsis on effective therapies targeting both immune-mediated responses and neurodegenerative processes is appointed. Oxidative stress has been also implicated in both the inflammatory and neurodegenerative pathological mechanisms underlying MS. The role of redox metabolism in MS is thus also reported, with particular focus on the latest improvements in the identification of oxidative stress as a potential new therapeutic target.
Export Options
About this article
Cite this article as:
Chiurchiu Valerio, Novel Targets in Multiple Sclerosis: To Oxidative Stress and Beyond, Current Topics in Medicinal Chemistry 2014; 14 (22) . https://dx.doi.org/10.2174/1568026614666141203143801
DOI https://dx.doi.org/10.2174/1568026614666141203143801 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clinical Development of Experimental Virus-Mediated Gene Therapy for Malignant Glioma
Anti-Cancer Agents in Medicinal Chemistry West Nile Virus NS2B/NS3 Protease As An Antiviral Target
Current Medicinal Chemistry Patent Annotations
Recent Patents on Anti-Infective Drug Discovery Design, Synthesis and Biological Evaluation of Antipicornaviral Pyrrole-Containing Peptidomimetics
Protein & Peptide Letters Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies
Current Alzheimer Research Innate Immunity in Alzheimer’s Disease: A Complex Affair
CNS & Neurological Disorders - Drug Targets Immunological Mechanisms of Neuropsychiatric Lupus
Current Immunology Reviews (Discontinued) Intracranial MR Dynamics in Clinically Diagnosed Alzheimers Disease: The Emerging Concept of “Pulse Wave Encephalopathy”
Current Alzheimer Research TNF-α Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets
Current Alzheimer Research Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming
Current Stem Cell Research & Therapy Crosstalk between Gut Microbiota and the Central Nervous System in Multiple Sclerosis: Strengths, Weaknesses, Opportunities and Threats Analysis of the Use of An Experimental Model
CNS & Neurological Disorders - Drug Targets Taking Advantage of Viral Immune Evasion: Virus-Derived Proteins Represent Novel Biopharmaceuticals
Current Medicinal Chemistry Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
Current Genomics Could Hippocampal Neurogenesis be a Future Drug Target for Treating Temporal Lobe Epilepsy?
CNS & Neurological Disorders - Drug Targets Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy
Current Pharmaceutical Design Antibodies Against Refolded Recombinant Envelope Protein (Domain III) of Japanese Encephalitis Virus Inhibit the JEV Infection to Porcine Stable Kidney Cells
Protein & Peptide Letters Antiidiotype-Derived Killer Peptides As New Potential Tools to Combat HIV-1 and AIDS-Related Opportunistic Pathogens
Anti-Infective Agents in Medicinal Chemistry Autophagy: For Better or for Worse, in Good Times or in Bad Times …
Current Molecular Medicine Toll-Like Receptor System in the Human Endometrium
Current Immunology Reviews (Discontinued) RNA Sensors as a Mechanism of Innate Immune Evasion among SARSCoV2, HIV and Nipah Viruses
Current Protein & Peptide Science