Abstract
Despite multiple sclerosis (MS) represents one of the most fascinating mystery of modern medicine due to its unknown etiology and the incomplete knowledge of a clear mechanism of pathogenesis, progress against this disease has made giant leaps. Current management of MS takes advantage of many disease- modifying therapeutics of anti-inflammatory and immunomodulatory nature, whose primary aims are halting immune responses during attacks, preventing new attacks and avoiding disability. In this review, a synopsis on effective therapies targeting both immune-mediated responses and neurodegenerative processes is appointed. Oxidative stress has been also implicated in both the inflammatory and neurodegenerative pathological mechanisms underlying MS. The role of redox metabolism in MS is thus also reported, with particular focus on the latest improvements in the identification of oxidative stress as a potential new therapeutic target.
Keywords: Inflammation, Multiple sclerosis, Neurodegeneration, Oxidative stress, Remyelination, Therapeutics.
Current Topics in Medicinal Chemistry
Title:Novel Targets in Multiple Sclerosis: To Oxidative Stress and Beyond
Volume: 14 Issue: 22
Author(s): Valerio Chiurchiu
Affiliation:
Keywords: Inflammation, Multiple sclerosis, Neurodegeneration, Oxidative stress, Remyelination, Therapeutics.
Abstract: Despite multiple sclerosis (MS) represents one of the most fascinating mystery of modern medicine due to its unknown etiology and the incomplete knowledge of a clear mechanism of pathogenesis, progress against this disease has made giant leaps. Current management of MS takes advantage of many disease- modifying therapeutics of anti-inflammatory and immunomodulatory nature, whose primary aims are halting immune responses during attacks, preventing new attacks and avoiding disability. In this review, a synopsis on effective therapies targeting both immune-mediated responses and neurodegenerative processes is appointed. Oxidative stress has been also implicated in both the inflammatory and neurodegenerative pathological mechanisms underlying MS. The role of redox metabolism in MS is thus also reported, with particular focus on the latest improvements in the identification of oxidative stress as a potential new therapeutic target.
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Cite this article as:
Chiurchiu Valerio, Novel Targets in Multiple Sclerosis: To Oxidative Stress and Beyond, Current Topics in Medicinal Chemistry 2014; 14 (22) . https://dx.doi.org/10.2174/1568026614666141203143801
DOI https://dx.doi.org/10.2174/1568026614666141203143801 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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