Abstract
Hydrogen sulfide (H2S) is regarded as one of the air pollutants with a rotten egg smell. However, it is recently discovered that endogenous H2S has important physiological and pathological functions. Cystathionine- β synthase (CBS) and cystathionine- γ lyase (CSE) play key roles in the synthesis of H2S, and CSE is also a major H2S-formation enzyme in the cardiovascular system. Vascular inflammation is one of the most important pathological processes in a variety of vascular diseases. The present review aimed at exploring the role of hydrogen sulfide and its signaling in vascular inflammation during vascular diseases including atherosclerosis, systemic hypertension, pulmonary hypertension (PAH), and vascular balloon injury.
Keywords: Atherosclerosis, balloon injury, hydrogen sulfide, hypertension, inflammation, NF-κB pathway, pulmonary hypertension.
Current Signal Transduction Therapy
Title:Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways
Volume: 9 Issue: 2
Author(s): Shasha Feng, Junbao Du, Selena Y. Chen, Wen Yu, Chaoshu Tang and Hongfang Jin
Affiliation:
Keywords: Atherosclerosis, balloon injury, hydrogen sulfide, hypertension, inflammation, NF-κB pathway, pulmonary hypertension.
Abstract: Hydrogen sulfide (H2S) is regarded as one of the air pollutants with a rotten egg smell. However, it is recently discovered that endogenous H2S has important physiological and pathological functions. Cystathionine- β synthase (CBS) and cystathionine- γ lyase (CSE) play key roles in the synthesis of H2S, and CSE is also a major H2S-formation enzyme in the cardiovascular system. Vascular inflammation is one of the most important pathological processes in a variety of vascular diseases. The present review aimed at exploring the role of hydrogen sulfide and its signaling in vascular inflammation during vascular diseases including atherosclerosis, systemic hypertension, pulmonary hypertension (PAH), and vascular balloon injury.
Export Options
About this article
Cite this article as:
Feng Shasha, Du Junbao, Chen Y. Selena, Yu Wen, Tang Chaoshu and Jin Hongfang, Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways, Current Signal Transduction Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574362409666141201204902
DOI https://dx.doi.org/10.2174/1574362409666141201204902 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Targeting the Renin-angiotensin System: Whats New?
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Clinical Features of Scleroderma-Like Disorders: A Challenge for the Rheumatologist
Current Rheumatology Reviews Non-Invasive Approaches to Visualize the Endothelin Axis In Vivo Using State-of-the-Art Molecular Imaging Modalities
Mini-Reviews in Medicinal Chemistry The Assessment of Platelet Activation in Antiplatelet Drug Development
Current Medicinal Chemistry Diabetic Retinopathy, Superoxide Damage and Antioxidants
Current Pharmaceutical Biotechnology Big Science for Small Cells: Systems Approaches for Platelets
Current Drug Targets Biology and Clinical Relevance of Mannose-Binding Lectin
Drug Design Reviews - Online (Discontinued) Novel Aspects in the Pathophysiology of Peripheral Vasculopathy in Systemic Sclerosis
Current Rheumatology Reviews Subject Index to Volume 4
Current Genomics Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases
Current Medicinal Chemistry Cardiovascular Effects of Omega-3 Free Fatty Acids.
Current Vascular Pharmacology GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment
Current Drug Targets Effects of Hypoxia and Ischemia on MicroRNAs in the Brain
Current Medicinal Chemistry Neonatal Systemic Thrombosis: An Updated Overview
Current Vascular Pharmacology The Obligatory Role of the Acetylcholine-Induced Endothelium-Dependent Contraction in Hypertension: Can Arachidonic Acid Resolve this Inflammation?
Current Pharmaceutical Design Inflammasome as a New Therapeutic Target for Diabetic Complications
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Myocardial Cellular Damage and Antioxidant Status in Off-Pump Versus On-Pump Coronary Artery Bypass Grafting - A Prospective Study
Vascular Disease Prevention (Discontinued) Glucose Blood Levels as a Therapeutic Target in Acute Ischaemic Stroke Setting
Current Topics in Medicinal Chemistry Editorial (Oxidative Stress in the Vascular Wall: A Useful Physiological Process or a Therapeutic Target in Vascular Disease?)
Recent Patents on Cardiovascular Drug Discovery The Role of Matrix Metalloproteinases in Essential Hypertension
Current Topics in Medicinal Chemistry