Abstract
Some novel analogs of 4H-1,4-benzothiazines were synthesized under environmentally benign solvent free conditions by one pot oxidative cyclocondensation of substituted 2- aminobenzenthiols with compounds having active methylene group and then converted in to sulfones. These compounds were examined as antitubercular agents against Mycobacterium tuberculosis H37Rv using REMA plate method. The best results have MICs from 6.4 to 8.8 μg/mL, comparable to phenothiazines. IR, NMR and mass spectral investigations are included for structural elucidation.
Keywords: 4H-1, 4-benzothiazines, antitubercular agents, green chemistry, REMA, sulfones.
Combinatorial Chemistry & High Throughput Screening
Title:Synthesis and Antitubercular Screening of Some Novel 4H-1,4- Benzothiazines and their Sulfones Under Environment Benign Solvent Free Conditions as Future Anti-Tubercular Agents
Volume: 18 Issue: 1
Author(s): Anjali Guleria, Dinesh K. Jangid, Naveen Gautam, Richa Lakhotia, Abhay Chowdhary and Dinesh C. Gautam
Affiliation:
Keywords: 4H-1, 4-benzothiazines, antitubercular agents, green chemistry, REMA, sulfones.
Abstract: Some novel analogs of 4H-1,4-benzothiazines were synthesized under environmentally benign solvent free conditions by one pot oxidative cyclocondensation of substituted 2- aminobenzenthiols with compounds having active methylene group and then converted in to sulfones. These compounds were examined as antitubercular agents against Mycobacterium tuberculosis H37Rv using REMA plate method. The best results have MICs from 6.4 to 8.8 μg/mL, comparable to phenothiazines. IR, NMR and mass spectral investigations are included for structural elucidation.
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Cite this article as:
Guleria Anjali, K. Jangid Dinesh, Gautam Naveen, Lakhotia Richa, Chowdhary Abhay and C. Gautam Dinesh, Synthesis and Antitubercular Screening of Some Novel 4H-1,4- Benzothiazines and their Sulfones Under Environment Benign Solvent Free Conditions as Future Anti-Tubercular Agents, Combinatorial Chemistry & High Throughput Screening 2015; 18 (1) . https://dx.doi.org/10.2174/1386207317666141126164147
DOI https://dx.doi.org/10.2174/1386207317666141126164147 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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