Abstract
The scenario of tuberculosis has gone deadly due to its high prevalence and emergence of widespread drug resistance. It is now high time to develop novel antimycobacterial strategies and to understand novel mechanisms of existing antimycobacterial compounds so that we are equipped with newer tuberculosis controlling molecules in the days to come. Iron has proven to be essential for pathogenesis of tuberculosis and retinoic acid is known to influence the iron metabolism pathway. Retenoic acid is also known to exhibit antitubercular effect in in vivo system. Therefore there is every possibility that retinoic acid by affecting the iron metabolism pathway exhibits its antimycobacterial effect. These aspects are reviewed in the present manuscript for understanding the antimycobacterial role of retinoic acid in the context of iron metabolism and other immunological aspects.
Keywords: Antitubercular drug, cholesterol, iron, phagosome, retinoic acid, tuberculosis.
Current Pharmaceutical Biotechnology
Title:Retinoic Acid and Iron Metabolism: A Step Towards Design of a Novel Antitubercular Drug
Volume: 15 Issue: 12
Author(s): Surajit Chakraborty, Rajasri Bhattacharyya, Kirtimaan Sayal and Dibyajyoti Banerjee
Affiliation:
Keywords: Antitubercular drug, cholesterol, iron, phagosome, retinoic acid, tuberculosis.
Abstract: The scenario of tuberculosis has gone deadly due to its high prevalence and emergence of widespread drug resistance. It is now high time to develop novel antimycobacterial strategies and to understand novel mechanisms of existing antimycobacterial compounds so that we are equipped with newer tuberculosis controlling molecules in the days to come. Iron has proven to be essential for pathogenesis of tuberculosis and retinoic acid is known to influence the iron metabolism pathway. Retenoic acid is also known to exhibit antitubercular effect in in vivo system. Therefore there is every possibility that retinoic acid by affecting the iron metabolism pathway exhibits its antimycobacterial effect. These aspects are reviewed in the present manuscript for understanding the antimycobacterial role of retinoic acid in the context of iron metabolism and other immunological aspects.
Export Options
About this article
Cite this article as:
Chakraborty Surajit, Bhattacharyya Rajasri, Sayal Kirtimaan and Banerjee Dibyajyoti, Retinoic Acid and Iron Metabolism: A Step Towards Design of a Novel Antitubercular Drug, Current Pharmaceutical Biotechnology 2014; 15 (12) . https://dx.doi.org/10.2174/1389201015666141126121639
DOI https://dx.doi.org/10.2174/1389201015666141126121639 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Meet Our Editorial Board Member
Current Respiratory Medicine Reviews Safety of Using Copper Oxide in Medical Devices and Consumer Products
Current Chemical Biology Expression, Purification, Crystallization and Preliminary X-Ray Crystallographic Analysis of the Resuscitation Promoting Factor Interacting Protein RipA from M. tuberculosis
Protein & Peptide Letters Leishmaniasis: History, Evolution of Treatment and the Need for New Drugs
Current Biotechnology 4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors
Medicinal Chemistry Immunity to Bacterial Infections
Current Immunology Reviews (Discontinued) Genotyping and Drug Susceptibility Patterns of <i>M. Tuberculosis</i> Isolated from HIV Seropositive Patients in Tehran Iran
Current HIV Research The Impending Renaissance in Discovery & Development of Natural Products
Current Topics in Medicinal Chemistry Microbial Genomics and Novel Antibiotic Discovery: New Technology to Search for New Drugs
Current Pharmaceutical Design Development and Validation of a Fast Reversed Phase Liquid Chromatographic Method for the Analysis of Ethionamide in Dosage Forms
Current Pharmaceutical Analysis Pharmacogenetics of Phase I and Phase II Drug Metabolism
Current Pharmaceutical Design Comparison of Protease Inhibitor (PI) Resistance-Associated Mutations Between PI-Naive and PI-Experienced HIV-1 Infected Patients in Thailand Where Subtype A/E is Predominant
Current HIV Research Lipids as Biomarkers of Cancer and Bacterial Infections
Current Medicinal Chemistry New Approaches for Anti-Infective Drug Discovery: Antibiotics, Vaccines and Beyond
Current Drug Targets - Infectious Disorders Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents
Current Microwave Chemistry A Case of Pulmonary Tuberculosis Mimicking as Diffuse Alveolar Hemorrhage: A Case Report
New Emirates Medical Journal Induction of Cytochromes P450
Current Drug Metabolism Patent Selections
Recent Patents on Anti-Infective Drug Discovery Inflammatory Caspases: Targets for Novel Therapies
Current Pharmaceutical Design Systemic Vasculitis: An Epidemiological Perspective
Current Immunology Reviews (Discontinued)