Abstract
Cu-catalyzed N-arylation of amides commonly known as Goldberg reaction is an important transformation in organic synthesis for the construction of pharmaceuticals and fine chemicals. This is the first review in this area which exclusively deals with recent developments in Goldberg reactions with special focus on mechanistic aspects, catalyst development as well as on the recent applications of this reaction in drug synthesis.
Keywords: amides, arylations, C-N coupling, catalysis, copper, Goldberg reaction.
Mini-Reviews in Organic Chemistry
Title:Goldberg Reaction: Development, Mechanistic Insights and Applications
Volume: 12 Issue: 1
Author(s): Anns Maria Thomas, Asha Sujatha and Gopinathan Anilkumar
Affiliation:
Keywords: amides, arylations, C-N coupling, catalysis, copper, Goldberg reaction.
Abstract: Cu-catalyzed N-arylation of amides commonly known as Goldberg reaction is an important transformation in organic synthesis for the construction of pharmaceuticals and fine chemicals. This is the first review in this area which exclusively deals with recent developments in Goldberg reactions with special focus on mechanistic aspects, catalyst development as well as on the recent applications of this reaction in drug synthesis.
Export Options
About this article
Cite this article as:
Thomas Maria Anns, Sujatha Asha and Anilkumar Gopinathan, Goldberg Reaction: Development, Mechanistic Insights and Applications, Mini-Reviews in Organic Chemistry 2015; 12 (1) . https://dx.doi.org/10.2174/1570193X11666141029002910
DOI https://dx.doi.org/10.2174/1570193X11666141029002910 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Repurposing of Chemotherapeutics to Combat COVID-19
Current Topics in Medicinal Chemistry Liposomal Targeting of Angiogenic Vasculature
Current Drug Delivery The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery and Postpartum are Reversed by Offspring Deprivation
Current Psychopharmacology Competition Between Tumor and Mononuclear Phagocyte System Causing the Low Tumor Distribution of Nanoparticles and Strategies to Improve Tumor Accumulation
Current Drug Delivery Surfactant Replacement Therapy in Pediatric Acute Lung Injury/Acute Respiratory Distress Syndrome
Current Respiratory Medicine Reviews The Current Outbreak of COVID-19 with Reference to India
Coronaviruses Current Advances in Novel SARS-CoV-2 Disease (COVID-19) Treatment and Intervention Strategies
Coronaviruses Antiviral Potential of Medicinal Plants for the COVID-19
Anti-Infective Agents Medicinal Chemistry of Paclitaxel and its Analogues
Current Medicinal Chemistry Pharmacophore and 3D-QSAR Studies on 1-Sulfonyl-4-acylpiperazines as Selective Cannabinoid-1 Receptor (CB1R) Inverse Agonists
Letters in Drug Design & Discovery An Efficient Cancer Classification Model for CT/MRI/PET Fused Images
Current Medical Imaging Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents
Mini-Reviews in Medicinal Chemistry Seroprevalence of Pertussis Antibodies and Infection Risk Among Female Medical Students
New Emirates Medical Journal Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections
Current Pharmaceutical Design Structure and Mechanism of Arylamine N-Acetyltransferases
Current Topics in Medicinal Chemistry 1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review
Mini-Reviews in Medicinal Chemistry Design, Synthesis and Biological Evaluation of a Library of Thiocarbazates and Their Activity as Cysteine Protease Inhibitors
Combinatorial Chemistry & High Throughput Screening Myocardial Infarction with and without ST-segment Elevation: a Contemporary Reappraisal of Similarities and Differences
Current Cardiology Reviews Visfatin/PBEF and Atherosclerosis-Related Diseases
Current Vascular Pharmacology Computational Biology and Drug Discovery: From Single-Target to Network Drugs
Current Bioinformatics