Abstract
The dopamine D2 receptor radiotracer [11C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [11C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent.
This work reports the optimisation of the production of [11C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [11C]Raclopride (100 GBq [11C]CO2, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis.
Keywords: 11Carbon, GPextent, optimization, raclopride.
Current Radiopharmaceuticals
Title:Optimisation of [11C]Raclopride Production Using a Synthra GPextent System
Volume: 7 Issue: 2
Author(s): Gary Perkins, Rajeev Sheth, Ivan Greguric and Giancarlo Pascali
Affiliation:
Keywords: 11Carbon, GPextent, optimization, raclopride.
Abstract: The dopamine D2 receptor radiotracer [11C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [11C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent.
This work reports the optimisation of the production of [11C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [11C]Raclopride (100 GBq [11C]CO2, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis.
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Cite this article as:
Perkins Gary, Sheth Rajeev, Greguric Ivan and Pascali Giancarlo, Optimisation of [11C]Raclopride Production Using a Synthra GPextent System, Current Radiopharmaceuticals 2014; 7 (2) . https://dx.doi.org/10.2174/1874471007666141021111635
DOI https://dx.doi.org/10.2174/1874471007666141021111635 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
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