Abstract
In the present study, the methanolic extract of roots of B. diffusa was standardized for the isolated phenolic aglycone (BD1) through HPTLC analysis and the content of BDE1 in the extract was found to be 5.755% w/w. The extract was studied for its nephroprotective and nephrocurative effects in cisplatin (10 mg/kg b.w.i.p.) induced nephrotoxicity in albino rats. Nephrocurative and nephroprotective potential of BDE was evaluated by monitoring the parameters serum urea, createnin, blood urea nitrogen and antioxidant parameters like lipid peroxidation, super oxide dismutase (SOD), catalase and NO scavenging activities. Treatment with single dose of Cisplatin led to significant (P<0.001) increase in the values of blood urea, serum createnine and blood urea nitrogen. These elevated values were found to be significantly (P<0.001) reduced and the levels of antioxidant parameters viz. superoxide dismutase, Catalase, Lipid peroxidation and nitric oxide levels, were found to be equivalent to healthy animals due to treatment with 300 mg/kg b.w.p.o of the BDE. The results are also supported with the histopathological studies on kidneys.
Keywords: Antioxidants, Boerhaavia diffusa, cisplatin, nephrotoxicity.
The Natural Products Journal
Title:Amelioration of Cisplatin Induced Nephrotoxicity by Standardized Methanolic Extract of Roots of Boerhaavia diffusa
Volume: 4 Issue: 3
Author(s): Bowlekar P. Babu and Gadgoli C. Harihar
Affiliation:
Keywords: Antioxidants, Boerhaavia diffusa, cisplatin, nephrotoxicity.
Abstract: In the present study, the methanolic extract of roots of B. diffusa was standardized for the isolated phenolic aglycone (BD1) through HPTLC analysis and the content of BDE1 in the extract was found to be 5.755% w/w. The extract was studied for its nephroprotective and nephrocurative effects in cisplatin (10 mg/kg b.w.i.p.) induced nephrotoxicity in albino rats. Nephrocurative and nephroprotective potential of BDE was evaluated by monitoring the parameters serum urea, createnin, blood urea nitrogen and antioxidant parameters like lipid peroxidation, super oxide dismutase (SOD), catalase and NO scavenging activities. Treatment with single dose of Cisplatin led to significant (P<0.001) increase in the values of blood urea, serum createnine and blood urea nitrogen. These elevated values were found to be significantly (P<0.001) reduced and the levels of antioxidant parameters viz. superoxide dismutase, Catalase, Lipid peroxidation and nitric oxide levels, were found to be equivalent to healthy animals due to treatment with 300 mg/kg b.w.p.o of the BDE. The results are also supported with the histopathological studies on kidneys.
Export Options
About this article
Cite this article as:
Babu P. Bowlekar and Harihar C. Gadgoli, Amelioration of Cisplatin Induced Nephrotoxicity by Standardized Methanolic Extract of Roots of Boerhaavia diffusa, The Natural Products Journal 2014; 4 (3) . https://dx.doi.org/10.2174/2210315504666141017000813
DOI https://dx.doi.org/10.2174/2210315504666141017000813 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Obesity and Metabolic Syndrome Affect the Cholinergic Transmission a nd Cognitive Functions
CNS & Neurological Disorders - Drug Targets Beyond Physical Exercise: The Role of Nutrition, Gut Microbiota and Nutraceutical Supplementation in Reducing Age-Related Sarcopenia
Current Aging Science Examination of QTc Values in Critically Ill Patients Diagnosed with Delirium and Prescribed Atypical Antipsychotics
Current Drug Safety An Eco-Friendly and Highly Efficient Synthesis of Pyrimidinones Using a TiO2-CNTs Nanocomposite Catalyst
Letters in Organic Chemistry Experimental Models of Abdominal Aortic Aneurysms: An Overview
Current Pharmaceutical Design Bidirectional Nature of Cardiovascular and Kidney Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Oral Disintegrating Tablets – An Updated Patent Perspective
Recent Patents on Drug Delivery & Formulation Genetic and Non-genetic Determinants of Cardiovascular Disease in South Asians
Current Diabetes Reviews Effects of Renin-Angiotensin-Aldosterone System Blockade on Diabetic Patients
Current Enzyme Inhibition Lack of Evidence for Deterioration in Endothelial Function Following Ticagrelor Treatment Cessation
Current Vascular Pharmacology Analytical Techniques for the Estimation of Perindopril Erbumine: A Review
Current Pharmaceutical Analysis Platelet Turnover in Atherothrombotic Disease
Current Pharmaceutical Design The Role of Angiotensin Type 1 Receptor in Inflammation and Endothelial Dysfunction
Recent Patents on Cardiovascular Drug Discovery Medicinal Properties of Mangiferin, Structural Features, Derivative Synthesis, Pharmacokinetics and Biological Activities
Mini-Reviews in Medicinal Chemistry Human Papilloma Virus Vaccine Associated Uveitis
Current Drug Safety Physiologic Responses in Anxiety
Current Psychiatry Reviews The Promise of Plant-Derived Substances as Inhibitors of Arginase
Mini-Reviews in Medicinal Chemistry Modeling the Effect of Selected Cyclodextrins on Nifedipine Solubility
Current Drug Discovery Technologies Progress Towards Discovery of Antifibrotic Drugs Targeting Synthesis of Type I Collagen
Current Medicinal Chemistry Current Status of Antiplatelet Therapy in Acute Coronary Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry