Abstract
In order to investigate the biological activity of novel thiourea compounds, some novel 1,2,3- thiadiazole derivatives containing 1,3,4-thiadiazole were synthesized under phase transfer catalyzed condition( PEG-600)by multi-step reactions. The chemical structures of all compounds were established by 1H NMR, FTIR, MS, and elemental analysis, and some of these compounds were investigated for fungicidal activity and plant growth regulatory activity. The bioassay results indicated that some of these compound exhibited moderate activities.
Keywords: 1, 2, 3-thiadiazole, 1, 3, 4-thiadiazole, bioactivity, synthesis, thiourea.
Letters in Drug Design & Discovery
Title:Synthesis and Biological Activity of Acylthiourea Derivatives Contain 1,2,3-thiadiazole and 1,3,4-thiadiazole
Volume: 12 Issue: 4
Author(s): Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Cheng-Xia Tan, Jian-Quan Weng and Xing-Hai Liu
Affiliation:
Keywords: 1, 2, 3-thiadiazole, 1, 3, 4-thiadiazole, bioactivity, synthesis, thiourea.
Abstract: In order to investigate the biological activity of novel thiourea compounds, some novel 1,2,3- thiadiazole derivatives containing 1,3,4-thiadiazole were synthesized under phase transfer catalyzed condition( PEG-600)by multi-step reactions. The chemical structures of all compounds were established by 1H NMR, FTIR, MS, and elemental analysis, and some of these compounds were investigated for fungicidal activity and plant growth regulatory activity. The bioassay results indicated that some of these compound exhibited moderate activities.
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Cite this article as:
Yang Ming-Yan, Zhao Wen, Sun Zhao-Hui, Tan Cheng-Xia, Weng Jian-Quan and Liu Xing-Hai, Synthesis and Biological Activity of Acylthiourea Derivatives Contain 1,2,3-thiadiazole and 1,3,4-thiadiazole, Letters in Drug Design & Discovery 2015; 12 (4) . https://dx.doi.org/10.2174/1570180811666141010000435
DOI https://dx.doi.org/10.2174/1570180811666141010000435 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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