Abstract
This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers the key mechanisms of antitumor action of natural PPhs against cancer cells.
Keywords: Chemotherapy, flavonoids, lignans, oncology, polyphenols, prostate cancer, stilbenes, tannins.
Current Bioactive Compounds
Title:Dietary Polyphenols for Prostate Cancer Therapy
Volume: 10 Issue: 2
Author(s): Yan A. Ivanenkov, Nina V. Chufarova, Mark S. Veselov and Alexander G. Majouga
Affiliation:
Keywords: Chemotherapy, flavonoids, lignans, oncology, polyphenols, prostate cancer, stilbenes, tannins.
Abstract: This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers the key mechanisms of antitumor action of natural PPhs against cancer cells.
Export Options
About this article
Cite this article as:
Ivanenkov A. Yan, Chufarova V. Nina, Veselov S. Mark and Majouga G. Alexander, Dietary Polyphenols for Prostate Cancer Therapy, Current Bioactive Compounds 2014; 10 (2) . https://dx.doi.org/10.2174/157340721002141001102524
DOI https://dx.doi.org/10.2174/157340721002141001102524 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Molecule of the Month
Current Topics in Medicinal Chemistry Testosterone Deficiency Syndrome: Cellular and Molecular Mechanism of Action
Current Aging Science Anti-Cancer Therapies that Utilize Cell Penetrating Peptides
Recent Patents on Anti-Cancer Drug Discovery Pharmaceutical Nanotechnology United States Patent Watch (April – June 2015)
Pharmaceutical Nanotechnology Irradiation Toxicity and Inflammatory Bowel Diseases (IBD): Review
Reviews on Recent Clinical Trials Targeted Angiogenesis Therapy in Head and Neck Squamous Cell Carcinomas
Current Angiogenesis (Discontinued) Preparation, Pharmacokinetic and Application of Gold Nanoclusters (AuNCs) in Tumor Treatment
Current Medicinal Chemistry Targeting the PI3K/AKT/mTOR Signaling Pathway in Medulloblastoma
Current Molecular Medicine Patent Selections
Recent Patents on Biomarkers High Mobility Group Box-1 (HMGB1): A Potential Target in Therapeutics
Current Drug Targets Modeling the Interactions Between α1-Adrenergic Receptors and Their Antagonists
Current Computer-Aided Drug Design Neurotrophic Factors in Combination: A Possible new Therapeutic Strategy to Influence Pathophysiology of Spinal Cord Injury and Repair Mechanisms
Current Pharmaceutical Design Small Molecules for Immunomodulation in Cancer: A Review
Anti-Cancer Agents in Medicinal Chemistry Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives
Current Drug Targets Use of Grape Polyphenols for Promoting Human Health: A Review of Patents
Recent Patents on Food, Nutrition & Agriculture NPY Y1 and Y5 Receptor Selective Antagonists as Anti-Obesity Drugs
Current Topics in Medicinal Chemistry Induction of Antitumor Immune Responses with Recombinant Lentivector: Role of Skin Derived DCs
Current Cancer Therapy Reviews Antitumor Effect of Cycle Inhibiting Factor Expression in Colon Cancer <i>via Salmonella</i> VNP20009
Anti-Cancer Agents in Medicinal Chemistry Role of Interleukin-17F in Asthma
Inflammation & Allergy - Drug Targets (Discontinued) Nucleic Acid Carrier Systems Based on Polyethylenimine Conjugates for the Treatment of Metastatic Tumors
Current Medicinal Chemistry