The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target

Title:The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target

Volume: 14 Issue: 7

Author(s): Haleh Vosgha, Ali Salajegheh, Robert Anthony Smith and Alfred King-Yin Lam

Affiliation:

Keywords: Carcinoma, cancer, miRNA-205, microRNA, oncogene, tumour suppressor gene.

Abstract: Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy.

Cite this article as:

Vosgha Haleh, Salajegheh Ali, Smith Anthony Robert and Lam King-Yin Alfred, The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target, Current Cancer Drug Targets 2014; 14 (7) . https://dx.doi.org/10.2174/156800961407140926105634