Abstract
A mild and economical method to prepare vildagliptin had been reported with a good yield. In this paper, vildagliptin was synthesized from L-proline and 3-amino-1-adamantanol through chloride acetylation, amination, dehydration and substitution. The total yield of the target compound was 59%.
Keywords: Economical, synthesize, vildagliptin.
Letters in Organic Chemistry
Title:A Facile and Economical Method to Synthesize Vildagliptin
Volume: 11 Issue: 10
Author(s): Yu Deng, Anmin Wang, Zhu Tao, Yingjie Chen, Xinmei Pan and Xiangnan Hu
Affiliation:
Keywords: Economical, synthesize, vildagliptin.
Abstract: A mild and economical method to prepare vildagliptin had been reported with a good yield. In this paper, vildagliptin was synthesized from L-proline and 3-amino-1-adamantanol through chloride acetylation, amination, dehydration and substitution. The total yield of the target compound was 59%.
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Cite this article as:
Deng Yu, Wang Anmin, Tao Zhu, Chen Yingjie, Pan Xinmei and Hu Xiangnan, A Facile and Economical Method to Synthesize Vildagliptin, Letters in Organic Chemistry 2014; 11 (10) . https://dx.doi.org/10.2174/1570178611666140922121805
DOI https://dx.doi.org/10.2174/1570178611666140922121805 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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