Abstract
Type I diabetes mellitus (TIDM), a devastating health issue in all over the world, has been treated by successful transplantation of insulin secreting pancreatic islets. However, serious limitations such as the requirement of immunosuppressive drugs for recipient patients, side effects as a result of long-term use of drugs, and reduced functionality of islets at the transplantation site remain. Bioartificial pancreas that includes islets encapsulated within semi-permeable membrane has been considered as a promising approach to address these requirements. Many studies have focused on micro or nanobased islet immunoisolation systems and tested the efficacy of encapsulated islets using in vitro and in vivo platforms. In this review, we address current progress and obstacles for the development of a bioartificial pancreas using micro/nanobased systems for encapsulation of islets.
Keywords: Bioartificial pancreas, islet encapsulation, type I diabetes mellitus, immunoisolation, islet transplantation, micro/ nano-based encapsulation.
Current Pharmaceutical Biotechnology
Title:Design of Bioartificial Pancreas with Functional Micro/Nano-Based Encapsulation of Islets
Volume: 15 Issue: 7
Author(s): Burcu Kepsutlu, Caner Nazli, Tugba Bal Bal and Seda Kizilel
Affiliation:
Keywords: Bioartificial pancreas, islet encapsulation, type I diabetes mellitus, immunoisolation, islet transplantation, micro/ nano-based encapsulation.
Abstract: Type I diabetes mellitus (TIDM), a devastating health issue in all over the world, has been treated by successful transplantation of insulin secreting pancreatic islets. However, serious limitations such as the requirement of immunosuppressive drugs for recipient patients, side effects as a result of long-term use of drugs, and reduced functionality of islets at the transplantation site remain. Bioartificial pancreas that includes islets encapsulated within semi-permeable membrane has been considered as a promising approach to address these requirements. Many studies have focused on micro or nanobased islet immunoisolation systems and tested the efficacy of encapsulated islets using in vitro and in vivo platforms. In this review, we address current progress and obstacles for the development of a bioartificial pancreas using micro/nanobased systems for encapsulation of islets.
Export Options
About this article
Cite this article as:
Kepsutlu Burcu, Nazli Caner, Bal Tugba Bal and Kizilel Seda, Design of Bioartificial Pancreas with Functional Micro/Nano-Based Encapsulation of Islets, Current Pharmaceutical Biotechnology 2014; 15 (7) . https://dx.doi.org/10.2174/1389201015666140915145709
DOI https://dx.doi.org/10.2174/1389201015666140915145709 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Stage A: Can Heart Failure Be Prevented?
Current Cardiology Reviews Buxus sempervirens L Improves Streptozotocin-induced Diabetes Mellitus in Rats
Cardiovascular & Hematological Disorders-Drug Targets Diabetes and Nutritional Screening in Post-Bariatric Patients
Current Diabetes Reviews Preface
Current Diabetes Reviews Pharmacogenetics of the Glucagon-like Peptide-1 Receptor Agonist Liraglutide: A Step Towards Personalized Type 2 Diabetes Management
Current Pharmaceutical Design Carbon Monoxide and the Pancreas
Current Pharmaceutical Biotechnology A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century
Current Medicinal Chemistry Assessment of Pancreatic β-Cell Function: Review of Methods and Clinical Applications
Current Diabetes Reviews The Effects of Non-Steroidal Anti-Inflammatory Drugs (Selective and Non-Selective) on the Treatment of Periodontal Diseases
Current Pharmaceutical Design New Pharmacological Approaches to the Prevention of Myocardial Ischemia- Reperfusion Injury
Current Drug Targets Novel Biomarkers Assessing Endothelial Dysfunction: Role of microRNAs
Current Topics in Medicinal Chemistry subject Index To Volume 2
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Pharmacological Characteristics of Parenteral IGF-I Administration
Current Pharmaceutical Biotechnology G Protein-Activated Inwardly Rectifying Potassium Channels as Potential Therapeutic Targets
Current Pharmaceutical Design The Involvement of Metallothioneins in Mitochondrial Function and Disease
Current Protein & Peptide Science Peroxisome Proliferator-Activated Receptor ?? (PPAR??) and Atherosclerosis
Current Drug Targets - Cardiovascular & Hematological Disorders Novel Optical Techniques for Imaging Microcirculation in the Diabetic Foot
Current Pharmaceutical Design Recent Advances in Synthetic Chemistry of Diabetic Research
Mini-Reviews in Medicinal Chemistry Dampening the Progression of Dementia
Current Neurovascular Research Therapeutic Targets to Raise HDL in Patients at Risk or with Coronary Artery Disease
Current Vascular Pharmacology