Abstract
A serious flaw of many chemotherapeutics employed now for the (post-surgery) treatment of malignant tumors is their high cytotoxicity against vital organs. In addition, tumor cells that survive chemotherapy often show pronounced drug resistance against a wide range of therapeutics. Recently, glycyrrhetinic acid derivatives derived from a cheap and easy-to-obtain natural product have attracted pharmacological interest. Many derivatives of glycyrrhetinic acid showed good to excellent cytotoxicity and inhibited the proliferation of a wide range of human tumor cells. They act predominantly by apoptosis, thus making them an interesting and even fascinating starting point for the development of selective, effective and safe antitumor active drugs.
Keywords: Antitumor activity, apoptosis, glyccyrhizin, glycyrrhetinic acid.
Mini-Reviews in Organic Chemistry
Title:Recent Developments in the Synthesis of Antitumor-active Glycyrrhetinic Acid Derivatives
Volume: 11 Issue: 3
Author(s): Rene Csuk
Affiliation:
Keywords: Antitumor activity, apoptosis, glyccyrhizin, glycyrrhetinic acid.
Abstract: A serious flaw of many chemotherapeutics employed now for the (post-surgery) treatment of malignant tumors is their high cytotoxicity against vital organs. In addition, tumor cells that survive chemotherapy often show pronounced drug resistance against a wide range of therapeutics. Recently, glycyrrhetinic acid derivatives derived from a cheap and easy-to-obtain natural product have attracted pharmacological interest. Many derivatives of glycyrrhetinic acid showed good to excellent cytotoxicity and inhibited the proliferation of a wide range of human tumor cells. They act predominantly by apoptosis, thus making them an interesting and even fascinating starting point for the development of selective, effective and safe antitumor active drugs.
Export Options
About this article
Cite this article as:
Csuk Rene, Recent Developments in the Synthesis of Antitumor-active Glycyrrhetinic Acid Derivatives, Mini-Reviews in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/1570193X1103140915105049
DOI https://dx.doi.org/10.2174/1570193X1103140915105049 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
General Anesthetics in Brain Injury: Friends or Foes?
Current Pharmaceutical Design The Host Complement System and Arbovirus Pathogenesis
Current Drug Targets Perspectives in Genomics The Future of Fungi in ‘omics’ era
Current Genomics Tuberculosis Infections of the Central Nervous System
Central Nervous System Agents in Medicinal Chemistry A Scientometrics Analysis and Visualization of Depressive Disorder
Current Neuropharmacology Beyond Cholinesterase Inhibition: Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Multi-Target Drugs for Neglected Diseases
Current Pharmaceutical Design Oncolytic HSV-1 Virotherapy: Clinical Experience and Opportunities for Progress
Current Pharmaceutical Biotechnology MRI of Central Nervous System (CNS) Vasculitis
Current Medical Imaging Anti-Viral
Current Bioactive Compounds Peptides Targeting Toll-Like Receptor Signalling Pathways for Novel Immune Therapeutics
Current Pharmaceutical Design Patent Selections
Recent Patents on Anti-Cancer Drug Discovery Evasion of Host Immunity by Virulent Salmonella: Implications for Vaccine Design
Current Medicinal Chemistry Peptide-Mediated Cellular Delivery of Oligonucleotide-Based Therapeutics In Vitro: Quantitative Evaluation of Overall Efficacy Employing Easy to Handle Reporter Systems
Current Pharmaceutical Design Tandem Repeat Peptide Strategy for the Design of Neurotrophic Factor Mimetics
CNS & Neurological Disorders - Drug Targets Dementia Etiologies and Remedies in Traditional Persian Medicine; A Review of Medicinal Plants and Phytochemistry
Current Drug Metabolism Agonists of the Tissue-Protective Erythropoietin Receptor in the Treatment of Parkinson’s Disease
Current Topics in Medicinal Chemistry 11C-verapamil to Assess P-gp Function in Human Brain During Aging,Depression and Neurodegenerative Disease
Current Topics in Medicinal Chemistry Is there a Teratogenicity Risk Associated with Cannabis and Synthetic Cannabimimetics’ (‘Spice’) Intake?
CNS & Neurological Disorders - Drug Targets What Animal Models are Best to Test Novel Rheumatoid Arthritis Therapies?
Current Rheumatology Reviews