Abstract
The industrial production of recombinant proteins preferentially requires the generation of stable cell lines expressing proteins in a quick, relatively facile, and a reproducible manner. Different methods are used to insert exogenous DNA into the host cell, and choosing the appropriate producing cell is of paramount importance for the efficient production and quality of the recombinant protein. This review addresses the advances in recombinant protein production in mammalian cell lines, according to key patents from the last 30 years.
Keywords: Mammalian expression system, patents in biopharmaceuticals, recombinant protein.
Recent Patents on Biotechnology
Title:Patents in Therapeutic Recombinant Protein Production Using Mammalian Cells
Volume: 8 Issue: 2
Author(s): Virginia Picanco-Castro, Marcela Cristina Correa de Freitas, Aline de Sousa Bomfim and Elisa Maria de Sousa Russo
Affiliation:
Keywords: Mammalian expression system, patents in biopharmaceuticals, recombinant protein.
Abstract: The industrial production of recombinant proteins preferentially requires the generation of stable cell lines expressing proteins in a quick, relatively facile, and a reproducible manner. Different methods are used to insert exogenous DNA into the host cell, and choosing the appropriate producing cell is of paramount importance for the efficient production and quality of the recombinant protein. This review addresses the advances in recombinant protein production in mammalian cell lines, according to key patents from the last 30 years.
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Picanco-Castro Virginia, Freitas Cristina Correa de Marcela, Bomfim de Sousa Aline and Russo Maria de Sousa Elisa, Patents in Therapeutic Recombinant Protein Production Using Mammalian Cells, Recent Patents on Biotechnology 2014; 8 (2) . https://dx.doi.org/10.2174/1872208309666140904120404
DOI https://dx.doi.org/10.2174/1872208309666140904120404 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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