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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Anti-Metastatics: An Overview of Drug Candidates in Current Pipelines

Author(s): Anne Schaap-Nutt, Dane A. Thyssen, David W. Drell and Frank Entschladen

Volume 20, Issue 42, 2014

Page: [6522 - 6528] Pages: 7

DOI: 10.2174/1381612820666140826152610

Price: $65

Abstract

As the number of novel drugs that have entered the market in oncology has slowed in recent years, there has been a dramatic shift towards new therapeutic approaches. The majority of cancer patients die from metastasis formation, which has prompted the pharmaceutical industry to begin to investigate a new class of agents: anti-metastatics. This review provides an overview of the targets, mechanisms of action, and drug substances currently in the pharma pipeline to inhibit tumor cell migration and metastasis formation.

Keywords: Metastasis, invasion, cell migration, signal transduction.


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