Abstract
The emergence of drug resistant strains of important human pathogens has created an urgent necessity to find new targets and novel antitubercular agents. According to the literature survey, we noticed that enoyl ACP reductase is one of the most promising targets. This enzyme is the most important catalyst for the FAS II synthesis of mycolic acid, which is the most essential component of the mycobacterial cell wall. This review summarizes the progress made in the design of enoyl ACP reductase inhibitors and the role played by 3D-structure of the enzyme in drug design process.
Keywords: Drug design, Enoyl ACP reductase, Enoyl ACP reductase inhibitors, FAS-II.
Mini-Reviews in Medicinal Chemistry
Title:Enoyl ACP Reductase as Effective Target for the Synthesized Novel Antitubercular Drugs: A-State-of-the-Art
Volume: 14 Issue: 8
Author(s): Shrinivas D. Joshi, Sheshagiri R. Dixit, Uttam A. More, Tejraj M. Aminabhavi, Venkatrao H. Kulkarni and Andanappa K. Gadad
Affiliation:
Keywords: Drug design, Enoyl ACP reductase, Enoyl ACP reductase inhibitors, FAS-II.
Abstract: The emergence of drug resistant strains of important human pathogens has created an urgent necessity to find new targets and novel antitubercular agents. According to the literature survey, we noticed that enoyl ACP reductase is one of the most promising targets. This enzyme is the most important catalyst for the FAS II synthesis of mycolic acid, which is the most essential component of the mycobacterial cell wall. This review summarizes the progress made in the design of enoyl ACP reductase inhibitors and the role played by 3D-structure of the enzyme in drug design process.
Export Options
About this article
Cite this article as:
Joshi D. Shrinivas, Dixit R. Sheshagiri, More A. Uttam, Aminabhavi M. Tejraj, Kulkarni H. Venkatrao and Gadad K. Andanappa, Enoyl ACP Reductase as Effective Target for the Synthesized Novel Antitubercular Drugs: A-State-of-the-Art, Mini-Reviews in Medicinal Chemistry 2014; 14 (8) . https://dx.doi.org/10.2174/1389557514666140820112524
DOI https://dx.doi.org/10.2174/1389557514666140820112524 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Structure and Functions of Bacterial Outer Membrane Protein A, A Potential Therapeutic Target for Bacterial Infection
Current Topics in Medicinal Chemistry Listeria-Based Anti-Infective Vaccine Strategies
Recent Patents on Anti-Infective Drug Discovery Increase in the Non-HIV-Related Deaths Among Aids Cases in the HAART Era
Current HIV Research 4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors
Medicinal Chemistry TLC Bioautography on Screening of Bioactive Natural Products: An Update Review
Current Analytical Chemistry Vitamin D Supplementation in Diabetic Foot Ulcers: A Current Perspective
Current Diabetes Reviews Thalidomide: A Banned Drug Resurged into Future Anticancer Drug
Current Drug Therapy Meet the Editorial Board:
Current Medicinal Chemistry Microwave-Assisted Synthesis and Bioactivities of Novel Quinoline Lactones
Letters in Organic Chemistry Drug Approval Process – In United States of America, European Union and India: A Review
Applied Clinical Research, Clinical Trials and Regulatory Affairs Tuberculosis and Diabetes Mellitus Co-morbidity
Current Respiratory Medicine Reviews Novel Drug-Induced Pulmonary Complications in Cancer Patients You Can Save Life!
Current Respiratory Medicine Reviews Hyperglycaemia and Vitamin D: A Systematic Overview
Current Diabetes Reviews Quinolones in the Search for New Anticancer Agents
Current Pharmaceutical Design Dendritic Cell Homeostasis in the Regulation of Self-Reactivity
Current Pharmaceutical Design Tuberculosis: An Inorganic Medicinal Chemistry Perspective
Current Medicinal Chemistry Phenolic and Organic Acids from <i>Spondias pinnata</i> Fruits
The Natural Products Journal Adjunctive Immunotherapeutic Efficacy of N-Formylated Internal Peptide of Mycobacterial Glutamine Synthetase in Mouse Model of Tuberculosis
Protein & Peptide Letters Current Understanding of Interactions between Nanoparticles and ABC Transporters in Cancer Cells
Current Medicinal Chemistry Hydrogel-clay Nanocomposites as Carriers for Controlled Release
Current Medicinal Chemistry