Abstract
Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hematopoietic cells. Complex interaction between these cells in the tumor microenvironment regulates tumor growth, progression, metastasis, and angiogenesis. Tumor-associated macrophages represent the major inflammatory cell population in tumors, which orchestrate various aspects of cancer. Cytokines and chemokines are major mediators of communication between cells in the tumor microenvironment. The concept of oncogene builds up an inflammatory pre-neoplastic microenvironment has emerged in the last few years. On the other hand, the development of induced pluripotent stem cells (iPSCs) unraveled a mystery in stem cell research. However, there are still some debates about iPSCs which should be answered by science.
Keywords: Cytokines, gastrointestinal cancer, inflammation, iPSCs, tumor microenvironment.
Current Stem Cell Research & Therapy
Title:Role of Inflammation and Tumor Microenvironment in the Development of Gastrointestinal Cancers: What Induced Pluripotent Stem Cells Can Do?
Volume: 10 Issue: 3
Author(s): Lei Zhang, Xiaojing Song, Yasuhiko Mohri and Liang Qiao
Affiliation:
Keywords: Cytokines, gastrointestinal cancer, inflammation, iPSCs, tumor microenvironment.
Abstract: Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hematopoietic cells. Complex interaction between these cells in the tumor microenvironment regulates tumor growth, progression, metastasis, and angiogenesis. Tumor-associated macrophages represent the major inflammatory cell population in tumors, which orchestrate various aspects of cancer. Cytokines and chemokines are major mediators of communication between cells in the tumor microenvironment. The concept of oncogene builds up an inflammatory pre-neoplastic microenvironment has emerged in the last few years. On the other hand, the development of induced pluripotent stem cells (iPSCs) unraveled a mystery in stem cell research. However, there are still some debates about iPSCs which should be answered by science.
Export Options
About this article
Cite this article as:
Zhang Lei, Song Xiaojing, Mohri Yasuhiko and Qiao Liang, Role of Inflammation and Tumor Microenvironment in the Development of Gastrointestinal Cancers: What Induced Pluripotent Stem Cells Can Do?, Current Stem Cell Research & Therapy 2015; 10 (3) . https://dx.doi.org/10.2174/1574888X09666140812112305
DOI https://dx.doi.org/10.2174/1574888X09666140812112305 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Hormetic Potential of Sulforaphane (SFN) in Switching Cells’ Fate Towards Survival or Death
Mini-Reviews in Medicinal Chemistry An Overview of Prospective Drugs for Type 1 and Type 2 Diabetes
Current Drug Targets Fiber Optic Sensors for Biomedical Applications
Current Analytical Chemistry Therapeutic Angiogenesis in Ischemic Tissues by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects
Current Stem Cell Research & Therapy Spinophilin: A New Tumor Suppressor at 17q21
Current Molecular Medicine Proteomics Approach to Illustrate Drug Action Mechanisms
Current Drug Discovery Technologies Potential Impacts of Prebiotics and Probiotics on Cancer Prevention
Anti-Cancer Agents in Medicinal Chemistry Opportunities and Challenges in Nano-structure Mediated Drug Delivery: Where Do We Stand?
Current Nanomedicine Gymnema sylvestre R. Br., an Indian Medicinal Herb: Traditional Uses, Chemical Composition, and Biological Activity
Current Pharmaceutical Biotechnology Biodefense Properties of Milk: The Role of Antimicrobial Proteins and Peptides
Current Pharmaceutical Design The c-Met Inhibitors: A New Class of Drugs in the Battle Against Advanced Nonsmall- Cell Lung Cancer
Current Pharmaceutical Design Acridine Orange is an Effective Anti-Cancer Drug that Affects Mitochondrial Function in Osteosarcoma Cells
Current Pharmaceutical Design Pharmacological Treatments for Obesity-Related Hypertension
Current Hypertension Reviews Cytotoxic and Antimicrobial Diterpenes Isolated from Hyptis dilatata
Current Bioactive Compounds Probiotics as an Alternative Strategy for Prevention and Treatment of Human Diseases: A Review
Inflammation & Allergy - Drug Targets (Discontinued) Current Status of Primary Cytoreductive Surgery for the Treatment of Advanced Epithelial Ovarian Cancer
Current Cancer Therapy Reviews Pancreatic Cancer in Obesity: Epidemiology, Clinical Observations, and Basic Mechanisms
Anti-Cancer Agents in Medicinal Chemistry Occurrence and Severity of Adverse Reactions of Immune Checkpoint Inhibitors (PD-1 and PD L1) Based on Mordovian Dispensary Data Analysis
Current Cancer Therapy Reviews Bioorganic Compounds Produced by the Fungus Monascus and their Use in Health Sciences and Medicine
Mini-Reviews in Organic Chemistry Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors
Anti-Cancer Agents in Medicinal Chemistry