Abstract
Since the time of Ehrlich (1854-1915) the antimicrobial activity of synthetic, non-chemotherapeutic compounds like phenothiazines and methylene blue, has been known. This article reports synthesis of some new 10Hphenothiazines, their sulfones and nucleosides, which have shown antimicrobial activity to a good extent against some selected strains of fungi, Gram positive and Gram negative bacteria leading us to a possibly potent class of antimicrobial agents. Reported 10H-phenothiazines were prepared using smiles rearrangement. These synthesized 10H-phenothiazines yield sulfones on oxidation with 30% hydrogen peroxide in glacial acetic acid and form nucleosides when treated with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate (sugar). Structural assignment is done by spectral and elemental investigations.
Keywords: Antimicrobial activity, nucleosides, 10H-phenothiazines, smiles rearrangement, sulfones.
Current Bioactive Compounds
Title:Synthesis and Biological Evaluation of Some Novel 10H-Phenothiazines, their Sulfones and Nucleosides as Possible Antimicrobial Agents
Volume: 10 Issue: 3
Author(s): Naveen Gautam, Anjali Guleria, Mukesh K. Sharma, Sudesh K. Gupta, Arun Goyal and D.C. Gautam
Affiliation:
Keywords: Antimicrobial activity, nucleosides, 10H-phenothiazines, smiles rearrangement, sulfones.
Abstract: Since the time of Ehrlich (1854-1915) the antimicrobial activity of synthetic, non-chemotherapeutic compounds like phenothiazines and methylene blue, has been known. This article reports synthesis of some new 10Hphenothiazines, their sulfones and nucleosides, which have shown antimicrobial activity to a good extent against some selected strains of fungi, Gram positive and Gram negative bacteria leading us to a possibly potent class of antimicrobial agents. Reported 10H-phenothiazines were prepared using smiles rearrangement. These synthesized 10H-phenothiazines yield sulfones on oxidation with 30% hydrogen peroxide in glacial acetic acid and form nucleosides when treated with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate (sugar). Structural assignment is done by spectral and elemental investigations.
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Cite this article as:
Gautam Naveen, Guleria Anjali, Sharma K. Mukesh, Gupta K. Sudesh, Goyal Arun and Gautam D.C., Synthesis and Biological Evaluation of Some Novel 10H-Phenothiazines, their Sulfones and Nucleosides as Possible Antimicrobial Agents, Current Bioactive Compounds 2014; 10 (3) . https://dx.doi.org/10.2174/1573407210666140728174315
DOI https://dx.doi.org/10.2174/1573407210666140728174315 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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