Alcohol Enhances HIV Infection of Cord Blood Monocyte-Derived Macrophages

Author(s): Dimitrios S. Mastrogiannis, Xu Wang, Min Dai, Jieliang Li, Yizhong Wang, Yu Zhou, Selin Sakarcan, Juliet Crystal Pena, Wenzhe Ho.

Journal Name:Current HIV Research

Volume 12 , Issue 4 , 2014

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Abstract:

Alcohol consumption or alcohol abuse is common among pregnant HIV+ women and has been identified as a potential behavioral risk factor for the transmission of HIV. In this study, we examined the impact of alcohol on HIV infection of cord blood monocyte-derived macrophages (CBMDM). We demonstrated that alcohol treatment of CBMDM significantly enhanced HIV infection of CBMDM. Investigation of the mechanisms of alcohol action on HIV demonstrated that alcohol inhibited the expression of several HIV restriction factors, including anti-HIV microRNAs, APOBEC3G and APOBEC3H. Additionally, alcohol also suppressed the expression of IFN regulatory factor 7 (IRF-7) and retinoic acid-inducible gene I (RIG-I), an intracellular sensor of viral infection. The suppression of these IFN regulatory factors was associated with reduced expression of type I IFN. These experimental findings suggest that maternal alcohol consumption may facilitate HIV infection, promoting vertical transmission of HIV.

Keywords: Alcohol, Anti-HIV miRNAs, Cord blood, Intracellular restriction factors, HIV.

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Article Details

VOLUME: 12
ISSUE: 4
Year: 2014
Page: [301 - 308]
Pages: 8
DOI: 10.2174/1570162X12666140721124923
Price: $58

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