Abstract
Studies about in vitro pellicle formation by slow-growing, pathogenic mycobacteria has just gained a new momentum, and in Mycobacterium tuberculosis, cells growing in this environment showed enhanced tolerance to antitubercular drugs. c-di-GMP, an ubiquitous bacterial second messenger, regulates phenotypes such as motility, biofilm formation and expression of acute virulence factors in several microorganisms. Recently, enzymes encoded by Rv1354c and Rv1357c were shown to produce and degrade c-di-GMP in vitro, respectively. Here we review the processes in which c-di-GMP regulates biofilm production and virulence in some human pathogens, discuss the possibility of these same processes existing in Mycobacterium tuberculosis, and how these mechanisms could impact the outcome of tuberculosis infection.
Keywords: Biofilm, c-di-GMP, EAL, GGDEF, virulence.
Current Respiratory Medicine Reviews
Title:Formation of Mycobacterial Pellicles In Vitro and their Possible Impact on Tuberculosis Infection
Volume: 10 Issue: 2
Author(s): Mario Alberto Flores-Valdez, Michel de Jesus Aceves-Sanchez, Saira Alejandra Montero-Perez, Perla Jazmín Vega-Dominguez and Cesar Pedroza-Roldan
Affiliation:
Keywords: Biofilm, c-di-GMP, EAL, GGDEF, virulence.
Abstract: Studies about in vitro pellicle formation by slow-growing, pathogenic mycobacteria has just gained a new momentum, and in Mycobacterium tuberculosis, cells growing in this environment showed enhanced tolerance to antitubercular drugs. c-di-GMP, an ubiquitous bacterial second messenger, regulates phenotypes such as motility, biofilm formation and expression of acute virulence factors in several microorganisms. Recently, enzymes encoded by Rv1354c and Rv1357c were shown to produce and degrade c-di-GMP in vitro, respectively. Here we review the processes in which c-di-GMP regulates biofilm production and virulence in some human pathogens, discuss the possibility of these same processes existing in Mycobacterium tuberculosis, and how these mechanisms could impact the outcome of tuberculosis infection.
Export Options
About this article
Cite this article as:
Flores-Valdez Alberto Mario, Aceves-Sanchez de Jesus Michel, Montero-Perez Alejandra Saira, Vega-Dominguez Jazmín Perla and Pedroza-Roldan Cesar, Formation of Mycobacterial Pellicles In Vitro and their Possible Impact on Tuberculosis Infection, Current Respiratory Medicine Reviews 2014; 10 (2) . https://dx.doi.org/10.2174/1573398X10666140717185630
DOI https://dx.doi.org/10.2174/1573398X10666140717185630 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pulmonary Drug Delivery: A Role for Polymeric Nanoparticles?
Current Topics in Medicinal Chemistry Recent Advances in Clinical Immunology, Endocrine & Metabolic Drugs: An Editorial Overview
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Cutaneous Adverse Drug Reactions Caused by Antituberculosis Drugs
Inflammation & Allergy - Drug Targets (Discontinued) p53-Induced Apoptosis and Inhibitors of p53
Current Medicinal Chemistry Investigation of the Role of Aromatic Residues in the Antimicrobial Peptide BuCATHL4B
Protein & Peptide Letters Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives
CNS & Neurological Disorders - Drug Targets Machine Learning Techniques and Drug Design
Current Medicinal Chemistry Exploration of Ion Channels in Mycobacterium tuberculosis: Implication on Drug Discovery and Potent Drug Targets Against Tuberculosis
Current Chemical Biology Nanomedicine in Therapeutic Intervention of Tuberculosis Meningitis
Current Nanoscience Synthesis and Biological Activity of 2,7-Naphthyridine Derivatives: An Overview
Current Organic Chemistry Vesicular Carriers for Skin Drug Delivery: The Pheroid™ Technology
Current Pharmaceutical Design Universal Nature of Spondyloarthropathy as a Reactive Disease, Reflecting Differential Sensitivities
Current Rheumatology Reviews Design and Synthesis of Some Newer Pyrimidine Hydroxamates as Histone Deacetylase Inhibitors
Current Enzyme Inhibition In-Situ Formation of Liposome of Rifampicin: Better Availability for Better Treatment
Current Drug Delivery Investigating Drug-induced Mitochondrial Toxicity: A Biosensor to Increase Drug Safety?
Current Drug Safety Novel Antimicrobial Agents for the Management of Maxillofacial and Neck Infections
Recent Patents on Anti-Infective Drug Discovery Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance
Current Neuropharmacology Inhibitors of Bacterial Transcription are Compounds for Potent Antimicrobial Drugs
Current Pharmaceutical Biotechnology Type 2 Diabetes and its Impact on the Immune System
Current Diabetes Reviews Renal & Ocular Targets for Therapy in Wegeners Granulomatosis
Inflammation & Allergy - Drug Targets (Discontinued)