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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

An Elevated Throughput Synthesis of Enureas Advanced by Microwave Irradiated Pd-Catalyzed C-N Coupling of Alkenyl Nonaflates

Author(s): Jignesh P. Dalvadi, Poojan K. Patel and Kishor H. Chikhalia

Volume 12, Issue 1, 2015

Page: [80 - 87] Pages: 8

DOI: 10.2174/1570179411666140716185213

Price: $65

Abstract

A novel and flexible synthetic approach to enureas is described. This convenient method has been developed for the Pd-catalyzed C-N coupling reaction of alkenyl nonaflates with a variety of ureas. A ferrocene based phosphine ligand, Joshiphos appeared noticeable as the most dynamic catalyst and K3PO4 in t-BuOH was established to be the most favorable base-solvent combination for the reaction. This catalyst system displayed amazing functional group tolerance and assigned quick synthesis of the entire series of enureas in excellent yields.

Keywords: Alkenyl nonaflate, aryl urea, Buchwald-Hartwig reaction, enurea, microwave assisted synthesis, Palladium catalyzed C-N coupling, urea.

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