Abstract
This study documents that mumps virus shares several peptide sequences with human proteins that, when altered, may be involved in oligospermia/azoospermia, sterility and testicular atrophy. Examples are sperm flagellar protein 2 and spermatogenesis and centriole-associated protein 1. The data invite to further investigate crossreactivity as a potential mechanism linking anti-mumps immune responses, alterations of spermatogenesis–associated antigens and male fertility disorders.
Keywords: Infertility, mumps immunogenicity, peptide crossreactivity, spermatogenesis-associated proteins, sterility.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Describing the Potential Crossreactome between Mumps Virus and Spermatogenesis-Associated Proteins
Volume: 14 Issue: 3
Author(s): Darja Kanduc
Affiliation:
Keywords: Infertility, mumps immunogenicity, peptide crossreactivity, spermatogenesis-associated proteins, sterility.
Abstract: This study documents that mumps virus shares several peptide sequences with human proteins that, when altered, may be involved in oligospermia/azoospermia, sterility and testicular atrophy. Examples are sperm flagellar protein 2 and spermatogenesis and centriole-associated protein 1. The data invite to further investigate crossreactivity as a potential mechanism linking anti-mumps immune responses, alterations of spermatogenesis–associated antigens and male fertility disorders.
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Cite this article as:
Kanduc Darja, Describing the Potential Crossreactome between Mumps Virus and Spermatogenesis-Associated Proteins, Endocrine, Metabolic & Immune Disorders - Drug Targets 2014; 14 (3) . https://dx.doi.org/10.2174/1871530314666140715115257
DOI https://dx.doi.org/10.2174/1871530314666140715115257 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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