Abstract
Protein folding is a spontaneous self-assembly process, which occurs in the biological system. Understanding this complex process not only helps in deciphering the mechanism involved in protein misfolding diseases but also helps in modeling in vitro and in vivo systems for testing the therapeutic strategies developed for the disease. Among the protein misfolding diseases, much emphasis has been given to Alzheimer’s disease because of its prevalence among elderly individuals and propensity to cause external damage to neurons, an effective cure for which is yet to be designed. Though amyloid fibrils are the major cause of neurotoxicity in Alzheimer’s disease, their mechanism of self-assembly during pathological conditions is still under active investigation. This review aims to understand the basic mechanism of amyloid fibril formation and how it can be characterized in different stages by various techniques. With this information, it is possible to design both in vitro and in vivo systems, which not only serves as model systems for understanding the mechanism of amyloid fibril formation but also helps to test new therapeutic strategies against the disease. This review also highlights the pros and cons of currently available in vitro and in vivo systems, which can aid the readers to select a suitable system for their further studies.
Keywords: Alzheimer’s disease, amyloid fibrils, animal models, characterization tools, protein misfolding diseases, selfassembling peptide.
Current Alzheimer Research
Title:Designing In Vitro Strategies and In Vivo Models for Alzheimer's Disease - Promises & Challenges
Volume: 11 Issue: 6
Author(s): Priyadharshini Kumaraswamy, Swaminathan Sethuraman and Uma Maheswari Krishnan
Affiliation:
Keywords: Alzheimer’s disease, amyloid fibrils, animal models, characterization tools, protein misfolding diseases, selfassembling peptide.
Abstract: Protein folding is a spontaneous self-assembly process, which occurs in the biological system. Understanding this complex process not only helps in deciphering the mechanism involved in protein misfolding diseases but also helps in modeling in vitro and in vivo systems for testing the therapeutic strategies developed for the disease. Among the protein misfolding diseases, much emphasis has been given to Alzheimer’s disease because of its prevalence among elderly individuals and propensity to cause external damage to neurons, an effective cure for which is yet to be designed. Though amyloid fibrils are the major cause of neurotoxicity in Alzheimer’s disease, their mechanism of self-assembly during pathological conditions is still under active investigation. This review aims to understand the basic mechanism of amyloid fibril formation and how it can be characterized in different stages by various techniques. With this information, it is possible to design both in vitro and in vivo systems, which not only serves as model systems for understanding the mechanism of amyloid fibril formation but also helps to test new therapeutic strategies against the disease. This review also highlights the pros and cons of currently available in vitro and in vivo systems, which can aid the readers to select a suitable system for their further studies.
Export Options
About this article
Cite this article as:
Kumaraswamy Priyadharshini, Sethuraman Swaminathan and Krishnan Maheswari Uma, Designing In Vitro Strategies and In Vivo Models for Alzheimer's Disease - Promises & Challenges, Current Alzheimer Research 2014; 11 (6) . https://dx.doi.org/10.2174/156720501106140711122129
DOI https://dx.doi.org/10.2174/156720501106140711122129 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review
Current Topics in Medicinal Chemistry Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) A Recent Update on the Role of Ghrelin in Glucose Homeostasis
Current Diabetes Reviews Update on Pharmacologic Retinal Vascular Toxicity
Current Pharmaceutical Design Different Attentional Modulation in the Visual Word Form Area and Parahippocampal Place Area
Neuroscience and Biomedical Engineering (Discontinued) Possible Use of Autologous Stem Cell Therapies for Alzheimers Disease
Current Alzheimer Research Apoptosis Induction by Thalidomide: Critical for Limb Teratogenicity but Therapeutic Potential in Idiopathic Pulmonary Fibrosis?
Current Molecular Pharmacology Progress of Biological Agents on Psoriatic Arthritis
Current Pharmaceutical Biotechnology Neuropharmacological Properties of the Essential Oil of Bergamot for the Clinical Management of Pain-Related BPSDs
Current Medicinal Chemistry Kv7 Channels as Targets for the Treatment of Pain
Current Pharmaceutical Design Dysregulation of Neurotrophic and Haematopoietic Growth Factors in Alzheimer’s Disease: From Pathophysiology to Novel Treatment Strategies
Current Alzheimer Research Adult Neurogenesis: Can Analysis of Cell Cycle Proteins Move Us “Beyond BrdU”?
Current Pharmaceutical Biotechnology Calcium Channel Blockade and Peroxisome Proliferator Activated Receptor γ Agonism Diminish Cognitive Loss and Preserve Endothelial Function During Diabetes Mellitus
Current Neurovascular Research Heat Shock Proteins as Suppressors of Accumulation of Toxic Prefibrillar Intermediates and Misfolded Proteins in Neurodegenerative Diseases
Current Pharmaceutical Biotechnology Human Opiorphin an Endogenous Inhibitor of Enkephalin-Inactivating Ectopeptidases that Displays Antinociception: A Review
Current Bioactive Compounds Investigational Positive Inotropic Agents for Acute Heart Failure
Cardiovascular & Hematological Disorders-Drug Targets An Investigative Approach to Treatment Modalities for Squamous Cell Carcinoma of Skin
Current Drug Delivery Prognostic Role of Sub-Clinical Hypothyroidism in Chronic Heart Failure Outpatients
Current Pharmaceutical Design RAGE and RAGE Ligands in Cancer
Current Molecular Medicine Propranolol Safety Profile in Children
Current Drug Safety