Abstract
Protein folding is a spontaneous self-assembly process, which occurs in the biological system. Understanding this complex process not only helps in deciphering the mechanism involved in protein misfolding diseases but also helps in modeling in vitro and in vivo systems for testing the therapeutic strategies developed for the disease. Among the protein misfolding diseases, much emphasis has been given to Alzheimer’s disease because of its prevalence among elderly individuals and propensity to cause external damage to neurons, an effective cure for which is yet to be designed. Though amyloid fibrils are the major cause of neurotoxicity in Alzheimer’s disease, their mechanism of self-assembly during pathological conditions is still under active investigation. This review aims to understand the basic mechanism of amyloid fibril formation and how it can be characterized in different stages by various techniques. With this information, it is possible to design both in vitro and in vivo systems, which not only serves as model systems for understanding the mechanism of amyloid fibril formation but also helps to test new therapeutic strategies against the disease. This review also highlights the pros and cons of currently available in vitro and in vivo systems, which can aid the readers to select a suitable system for their further studies.
Keywords: Alzheimer’s disease, amyloid fibrils, animal models, characterization tools, protein misfolding diseases, selfassembling peptide.
Current Alzheimer Research
Title:Designing In Vitro Strategies and In Vivo Models for Alzheimer's Disease - Promises & Challenges
Volume: 11 Issue: 6
Author(s): Priyadharshini Kumaraswamy, Swaminathan Sethuraman and Uma Maheswari Krishnan
Affiliation:
Keywords: Alzheimer’s disease, amyloid fibrils, animal models, characterization tools, protein misfolding diseases, selfassembling peptide.
Abstract: Protein folding is a spontaneous self-assembly process, which occurs in the biological system. Understanding this complex process not only helps in deciphering the mechanism involved in protein misfolding diseases but also helps in modeling in vitro and in vivo systems for testing the therapeutic strategies developed for the disease. Among the protein misfolding diseases, much emphasis has been given to Alzheimer’s disease because of its prevalence among elderly individuals and propensity to cause external damage to neurons, an effective cure for which is yet to be designed. Though amyloid fibrils are the major cause of neurotoxicity in Alzheimer’s disease, their mechanism of self-assembly during pathological conditions is still under active investigation. This review aims to understand the basic mechanism of amyloid fibril formation and how it can be characterized in different stages by various techniques. With this information, it is possible to design both in vitro and in vivo systems, which not only serves as model systems for understanding the mechanism of amyloid fibril formation but also helps to test new therapeutic strategies against the disease. This review also highlights the pros and cons of currently available in vitro and in vivo systems, which can aid the readers to select a suitable system for their further studies.
Export Options
About this article
Cite this article as:
Kumaraswamy Priyadharshini, Sethuraman Swaminathan and Krishnan Maheswari Uma, Designing In Vitro Strategies and In Vivo Models for Alzheimer's Disease - Promises & Challenges, Current Alzheimer Research 2014; 11 (6) . https://dx.doi.org/10.2174/156720501106140711122129
DOI https://dx.doi.org/10.2174/156720501106140711122129 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial (Thematic Issue: Ultrasonic Vocalizations in Rats: A Tool for the Investigation of Psychoactive Drugs and Neuropsychiatric Conditions)
Current Neuropharmacology Role of the Transglutaminase Enzymes in the Nervous System and their Possible Involvement in Neurodegenerative Diseases
Current Medicinal Chemistry Effect of Acute Administration of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine Hydrochloride (TC-2153) on Biogenic Amines Metabolism in Mouse Brain
Letters in Drug Design & Discovery Editorial:Cannabis: Neurological Correlates in Abuse and Medical Use
CNS & Neurological Disorders - Drug Targets Addressing the Health, Developmental and Social Outcomes of Children Exposed to Perinatal and Infectious Risks
Infectious Disorders - Drug Targets Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Trizbenzim, Cu-Trizbenzim and Zn-Trizbenzim as G-Quadruplex Inducing and Stabilizing Compounds on Human Telomeric Sequence and their Anticancer Properties
Anti-Cancer Agents in Medicinal Chemistry Improving Human Performance and Comfort Through Perception: Technological Applications for Space
Recent Progress in Space Technology (Discontinued) Left Anterior Temporal Lobe Sustains Naming in Alzheimers Dementia and Mild Cognitive Impairment
Current Alzheimer Research Lipid Biomarkers in Alzheimer's Disease
Current Alzheimer Research Differentiation of Glioblastoma and Lymphoma Using Feature Extraction and Support Vector Machine
CNS & Neurological Disorders - Drug Targets Mesenchymal Stem Cells: A New Generation of Therapeutic Agents as Vehicles in Gene Therapy
Current Gene Therapy Psychosocial Stress But Not Exercise Increases Cortisol and Reduces State Anxiety Levels in School Classes - Results from a Stressor Applicable in Large Group Settings
CNS & Neurological Disorders - Drug Targets Vitamin D, Sunlight, and the Epidemiology of Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry Molecular Targeting of Aberrant Transcription Factors in Leukemia: Strategies for RUNX1/ETO
Current Drug Targets Molecularly Imprinted Sensor for Ascorbic Acid Based on Gold Nanoparticles and Multiwalled Carbon Nanotubes
Current Analytical Chemistry The ERK 1 and 2 Pathway in the Nervous System: From Basic Aspects to Possible Clinical Applications in Pain and Visceral Dysfunction
Current Neuropharmacology Dysfunction of Glutamate Receptors in Microglia May Cause Neurodegeneration
Current Alzheimer Research Beyond the Cardiac Myofilament: Hypertrophic Cardiomyopathy- Associated Mutations in Genes that Encode Calcium-Handling Proteins
Current Molecular Medicine Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders
Current Neuropharmacology