Abstract
About 1 billion cardiomyocytes are lost in heart disease such as myocardial infarction; the regeneration capacity of cardiomyocytes is extremely low and the heart is unable to fix this damage naturally. In the past 20 years, multiple cells, such as skeletal myoblasts, bone marrow-derived cells, cardiac progenitor cells and pluripotent stem cells have been utilized to test the efficacy on heart repair, but these cells show different kinds of drawbacks. Recent studies have revealed that concomitant transplantation of endothelial cells and stem cells can significantly improve the efficacy of cell based heart repair. In this review, we describe the progress on these studies with an emphasis on endothelial cell facilitated stem cell therapy. We also summarize the beneficial mechanisms of endothelial cells in cardiac repair and point out the potential challenges for endothelial cell-facilitated-cell therapy to be adopted for clinical application.
Keywords: Cardiac repair, endothelial cells, stem cells.
Current Stem Cell Research & Therapy
Title:Endothelial Cells Facilitate Cell-Based Cardiac Repair: Progress and Challenge
Volume: 9 Issue: 5
Author(s): Ping Yuan and Xin Ma
Affiliation:
Keywords: Cardiac repair, endothelial cells, stem cells.
Abstract: About 1 billion cardiomyocytes are lost in heart disease such as myocardial infarction; the regeneration capacity of cardiomyocytes is extremely low and the heart is unable to fix this damage naturally. In the past 20 years, multiple cells, such as skeletal myoblasts, bone marrow-derived cells, cardiac progenitor cells and pluripotent stem cells have been utilized to test the efficacy on heart repair, but these cells show different kinds of drawbacks. Recent studies have revealed that concomitant transplantation of endothelial cells and stem cells can significantly improve the efficacy of cell based heart repair. In this review, we describe the progress on these studies with an emphasis on endothelial cell facilitated stem cell therapy. We also summarize the beneficial mechanisms of endothelial cells in cardiac repair and point out the potential challenges for endothelial cell-facilitated-cell therapy to be adopted for clinical application.
Export Options
About this article
Cite this article as:
Yuan Ping and Ma Xin, Endothelial Cells Facilitate Cell-Based Cardiac Repair: Progress and Challenge, Current Stem Cell Research & Therapy 2014; 9 (5) . https://dx.doi.org/10.2174/1574888X09666140710100143
DOI https://dx.doi.org/10.2174/1574888X09666140710100143 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Fermentation of Beet Juice Using Lactic Acid Bacteria and its Cytotoxic Activity Against Human Liver Cancer Cell Lines HepG2
Current Bioactive Compounds 1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology
Current Pharmaceutical Design Traditional and Alternative Therapies for Refractory Angina
Current Pharmaceutical Design Pre-eclampsia Versus Cardiovascular Disease Versus CRP
Current Hypertension Reviews Dietary Agents for Prostate Cancer Chemoprevention: An Overview
Current Cancer Therapy Reviews Atrial Conduction Disorders
Current Cardiology Reviews Editorial [Hot Topic: Cardiovascular Diagnostic Testing: Use and Limits of Biochemical Markers (Executive Editors: Aurelio Leone and Stefano Taddei)]
Current Pharmaceutical Design Management of the Metabolic Syndrome as a Strategy for Preventing the Macrovascular Complications of Type 2 Diabetes: Controversial Issues
Current Diabetes Reviews Hyperuricemia: Is it a Risk Factor for Vascular Endothelial Dysfunction and Associated Cardiovascular Disorders?
Current Hypertension Reviews Pharmacological and Biological Activities of Benzazepines: An Overview
Current Bioactive Compounds Platelet Turnover in Atherothrombotic Disease
Current Pharmaceutical Design Green Tea Attenuates Cardiovascular Remodeling and Metabolic Symptoms in High Carbohydrate-Fed Rats
Current Pharmaceutical Biotechnology Plant Troponoids: Chemistry, Biological Activity, and Biosynthesis
Current Medicinal Chemistry Teaching Pharmacogenetics in Low and Middle-Income Countries: Team Based Learning and Lessons Learned at the American University of Beirut
Current Pharmacogenomics and Personalized Medicine Potential Health Benefits of Berries
Current Nutrition & Food Science High Blood Pressure and the Risk of Stroke
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Role of ARBs in the Blood Hypertension Therapy and Prevention of Cardiovascular Events
Current Drug Targets Subject Index to Volume 3
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Inflammatory Biomarkers and Therapeutic Targets in Heart Failure
Current Medicinal Chemistry Antiepileptic Drugs During Pregnancy: Pharmacokinetics and Transplacental Transfer
Current Pharmaceutical Biotechnology