Abstract
The global burden of diabetes and cardiovascular disease (CVD) is increasing. Obesity is rapidly increasing worldwide and is associated with dyslipidaemia, metabolic syndrome (MetS) and type 2 diabetes (T2DM). Excess risks of T2DM and CVD are found in migrant Indian Asian and West African populations but with increasing urbanization similar changes are occurring in the original populations and are likely to predispose to a large increase in worldwide burden of CVD. Genetic and environmental factors interacting together play a role in the lipid patterns observed. Dyslipidaemia in the MetS associated with insulin resistance is characterised by an atherogenic lipid profile comprising elevated triglycerides, low high density lipoprotein cholesterol (HDL-C) and increased numbers of small dense low density lipoprotein particles. The pattern of dyslipidaemia varies across different ethnic groups with increases in triglycerides and a reduction in HDL-C being the commonest pattern in non-Caucasians. This review surveys the literature on dyslipidaemia in Indian Asian and West African populations and how it relates to CVD risk in those populations. It is important that dyslipidaemia and other conventional risk factors for CVD are adequately addressed and managed especially in high-risk populations
Keywords: Ethnicity, insulin resistance, triglycerides, HDL-C, cardiovascular disease, Indian Asian, African
Current Pharmaceutical Design
Title:Dyslipidaemia Related to Insulin Resistance and Cardiovascular Disease in South Asian and West African Populations
Volume: 20 Issue: 40
Author(s): Mfon Ewang-Emukowhate, Dilinika Perera and Anthony S. Wierzbicki DM
Affiliation:
Keywords: Ethnicity, insulin resistance, triglycerides, HDL-C, cardiovascular disease, Indian Asian, African
Abstract: The global burden of diabetes and cardiovascular disease (CVD) is increasing. Obesity is rapidly increasing worldwide and is associated with dyslipidaemia, metabolic syndrome (MetS) and type 2 diabetes (T2DM). Excess risks of T2DM and CVD are found in migrant Indian Asian and West African populations but with increasing urbanization similar changes are occurring in the original populations and are likely to predispose to a large increase in worldwide burden of CVD. Genetic and environmental factors interacting together play a role in the lipid patterns observed. Dyslipidaemia in the MetS associated with insulin resistance is characterised by an atherogenic lipid profile comprising elevated triglycerides, low high density lipoprotein cholesterol (HDL-C) and increased numbers of small dense low density lipoprotein particles. The pattern of dyslipidaemia varies across different ethnic groups with increases in triglycerides and a reduction in HDL-C being the commonest pattern in non-Caucasians. This review surveys the literature on dyslipidaemia in Indian Asian and West African populations and how it relates to CVD risk in those populations. It is important that dyslipidaemia and other conventional risk factors for CVD are adequately addressed and managed especially in high-risk populations
Export Options
About this article
Cite this article as:
Ewang-Emukowhate Mfon, Perera Dilinika and DM S. Wierzbicki Anthony, Dyslipidaemia Related to Insulin Resistance and Cardiovascular Disease in South Asian and West African Populations, Current Pharmaceutical Design 2014; 20 (40) . https://dx.doi.org/10.2174/1381612820666140620114948
DOI https://dx.doi.org/10.2174/1381612820666140620114948 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Immunosuppressant Drugs and Covid-19: Associated Risks, Drug-Drug Interactions and Contraindications
Coronaviruses Role of Coronary Microvascular Endothelial Dysfunction in the Development of Heart Failure
Current Cardiology Reviews Alcohol and the Cardiovascular System: A Double-Edged Sword
Current Pharmaceutical Design Donor-transmitted Anterior Myocardial Ischaemia in a Teenager: How to Proceed?
New Emirates Medical Journal Auto-Antibodies As Possible Markers and Mediators of Ischemic, Dilated, and Rhythmic Cardiopathies
Current Drug Targets Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Cardiac Structural and Electrical Remodeling: From Myocardial Cytology to Cardiodiabetology
Current Vascular Pharmacology Myotonic Dystrophies 1 and 2: Complex Diseases with Complex Mechanisms
Current Genomics Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?
Current Pharmaceutical Biotechnology A Brief History of ‘Lone’ Atrial Fibrillation: From ‘A Peculiar Pulse Irregularity’ to a Modern Public Health Concern
Current Pharmaceutical Design Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing
Current Vascular Pharmacology Endothelial Progenitor Cells and Vascular Biology in Diabetes Mellitus: Current Knowledge and Future Perspectives
Current Diabetes Reviews Gene Therapy Approaches to Ataxias
Current Gene Therapy The Concept of Titration can be Transposed to Fluid Management. But does is Change the Volumes? Randomised Trial on Pleth Variability Index During Fast-Track Colonic Surgery
Current Clinical Pharmacology Species Differences in Hepatocyte-Directed Gene Transfer: Implications for Clinical Translation
Current Gene Therapy Patent Selections:
Recent Patents on Drug Delivery & Formulation Energetic Metabolic Roles in Pulmonary Arterial Hypertension and Right Ventricular Remodeling
Current Pharmaceutical Design Targeted Nucleic Acid Delivery to Mitochondria
Current Gene Therapy Mitochondrial Involvement in Psychiatric Illness in Adults
Current Psychiatry Reviews Angiotensin-Converting Enzyme Inhibitors in Veterinary Medicine
Current Pharmaceutical Design The Woman’s Heart: Insights into New Potential Targeted Therapy
Current Medicinal Chemistry