Abstract
Depression is the most prevalent psychiatric disorder (16.6%) and is frequently associated with impairments in several areas. Sexual dysfunction (SD) is a prevalent problem with rates ranging from 40-45% in adult women and 20- 30% in adult men. A relationship between depression and sexual dysfunction has been shown in the literature although the mechanisms of this association are not yet clear. Many antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), list sexual dysfunction as a side effect. New drug alternatives with fewer side effects have been proposed, and bupropion is one of them. This study aims to review the literature on bupropion and its impact in sexual function on depressed subjects. Most of the studies have noted that bupropion is not only as effective as other antidepressants but has the advantage of a lower impact on sexual functioning. Some other studies have found that bupropion can even enhance sexual function in certain individuals. Bupropion is also effective, when combined with other antidepressants, in treating emergent sexual dysfunction. Bupropion may be an alternative treatment for depression that does not include the sexual side effects associated with most of the prescribed antidepressants available; however, additional research is required.
Keywords: Antidepressants, bupropion, depression, pharmacotherapy, review, sexual dysfunction.
CNS & Neurological Disorders - Drug Targets
Title:Bupropion in the Depression-Related Sexual Dysfunction: A Systematic Review
Volume: 13 Issue: 6
Author(s): Valeska M. Pereira, Oscar Arias-Carrion, Sergio Machado, Antonio E. Nardi and Adriana C. Silva
Affiliation:
Keywords: Antidepressants, bupropion, depression, pharmacotherapy, review, sexual dysfunction.
Abstract: Depression is the most prevalent psychiatric disorder (16.6%) and is frequently associated with impairments in several areas. Sexual dysfunction (SD) is a prevalent problem with rates ranging from 40-45% in adult women and 20- 30% in adult men. A relationship between depression and sexual dysfunction has been shown in the literature although the mechanisms of this association are not yet clear. Many antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), list sexual dysfunction as a side effect. New drug alternatives with fewer side effects have been proposed, and bupropion is one of them. This study aims to review the literature on bupropion and its impact in sexual function on depressed subjects. Most of the studies have noted that bupropion is not only as effective as other antidepressants but has the advantage of a lower impact on sexual functioning. Some other studies have found that bupropion can even enhance sexual function in certain individuals. Bupropion is also effective, when combined with other antidepressants, in treating emergent sexual dysfunction. Bupropion may be an alternative treatment for depression that does not include the sexual side effects associated with most of the prescribed antidepressants available; however, additional research is required.
Export Options
About this article
Cite this article as:
Pereira M. Valeska, Arias-Carrion Oscar, Machado Sergio, Nardi E. Antonio and Silva C. Adriana, Bupropion in the Depression-Related Sexual Dysfunction: A Systematic Review, CNS & Neurological Disorders - Drug Targets 2014; 13 (6) . https://dx.doi.org/10.2174/1871527313666140612112630
DOI https://dx.doi.org/10.2174/1871527313666140612112630 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-inflammatory Effect of Predimenol, A Bioactive Extract from <i>Phaleria
macrocarpa</i>, through the Suppression of NF-κB and COX-2
Recent Advances in Inflammation & Allergy Drug Discovery A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of the H<sub>3</sub> Receptor Antagonist, GSK239512 as a Monotherapy in Subjects with Mild-to-Moderate Alzheimer’s Disease
Current Alzheimer Research Current and Future Drugs for Appetite Regulation and Obesity Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery COVID-19: Challenges and its Technological Solutions using IoT
Current Medical Imaging Analysis of TLC-Bioautography and TLC-Spot Visualization of <i>Atropa accuminata</i> and <i>Atropa belladonna</i> Extracts as Antioxidant and Antibacterial Agents Against Human Pathogenic Bacteria
Current Pharmaceutical Analysis Combination Treatment in Alzheimers Disease: Results of a Randomized, Controlled Trial with Cerebrolysin and Donepezil
Current Alzheimer Research Recent Advances in Pathophysiology of Traumatic Brain Injury
Current Neuropharmacology A Pharmacological Review of Five Widely Used Traditional Medicinal Plants for Sedative-Hypnotic Effects in Bangladesh
Current Traditional Medicine Human Umbilical Cord Mesenchymal Stem Cell Therapy on Neuromyelitis Optica
Current Neurovascular Research Pain Management in Hematological Patients with Major Organ Dysfunctions and Comorbid Illnesses
Cardiovascular & Hematological Agents in Medicinal Chemistry Statins: Are They All the Same?
Current Drug Therapy Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences
Current Drug Targets Hypertension in Pregnancy: Clinical Manifestations and Treatment
Current Hypertension Reviews E-MHK-0103 (Mineraxin™): A Novel Nutraceutical with Biological Properties in Menopausal Conditions
Current Drug Metabolism Oxidative Stress and Antioxidant Potential of One Hundred Medicinal Plants
Current Topics in Medicinal Chemistry Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Induced Dyspepsia
Current Pharmaceutical Design TRPV1 Function in Health and Disease
Current Pharmaceutical Biotechnology Ofatumumab: A Novel Anti-CD20 Monoclonal Antibody for the Treatment of Chronic Lymphocytic Leukemia
Current Drug Therapy Nano-antimicrobials: A New Paradigm for Combating Mycobacterial Resistance
Current Pharmaceutical Design Glucose Blood Levels as a Therapeutic Target in Acute Ischaemic Stroke Setting
Current Topics in Medicinal Chemistry