Abstract
Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms responsible for the anti-carcinogenesis effects of garlic and its derivatives.
Keywords: Allyl sulfides, apoptosis, carcinogenesis, cell cycle, Garlic, organosulfur compounds.
Anti-Cancer Agents in Medicinal Chemistry
Title:Garlic-Derived Allyl Sulfides in Cancer Therapy
Volume: 14 Issue: 6
Author(s): Hai-Xia Cao, Ke-Xiang Zhu, Jian-Gao Fan and Liang Qiao
Affiliation:
Keywords: Allyl sulfides, apoptosis, carcinogenesis, cell cycle, Garlic, organosulfur compounds.
Abstract: Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms responsible for the anti-carcinogenesis effects of garlic and its derivatives.
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Cite this article as:
Cao Hai-Xia, Zhu Ke-Xiang, Fan Jian-Gao and Qiao Liang, Garlic-Derived Allyl Sulfides in Cancer Therapy, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (6) . https://dx.doi.org/10.2174/1871520614666140521120811
DOI https://dx.doi.org/10.2174/1871520614666140521120811 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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