Abstract
Neuroinflammation is presented in the acute phase brain damage as well as chronic diseases. Cells that are directly or indirectly involved in immune responses compose the central nervous system (CNS). Microglia are resident cells of the CNS and, as peripheral macrophages, are activated in presence of some cellular insult, producing a large number of cytokines and chemokines in order to remove toxins from the extracellular space. This activation can lead to a breakdown of the blood-brain barrier, production of reactive oxygen species that is involved in the progression of CNS damage as occurs in septic encephalopathy. Given the growing relevance of microglia in the area of neurotoxicology, we describe the role of microglia and the cellular mechanisms that activate these cells during sepsis. Thus, in this review we focused on the relationship between microglia and neuroinflammation associated with sepsis.
Keywords: Blood-brain barrier, CNS, encephalopathy, microglia, neuroinflammation, sepsis.
Current Neurovascular Research
Title:Neuroinflammation: Microglial Activation During Sepsis
Volume: 11 Issue: 3
Author(s): Monique Michels, Lucineia G. Danielski, Felipe Dal-Pizzol and Fabricia Petronilho
Affiliation:
Keywords: Blood-brain barrier, CNS, encephalopathy, microglia, neuroinflammation, sepsis.
Abstract: Neuroinflammation is presented in the acute phase brain damage as well as chronic diseases. Cells that are directly or indirectly involved in immune responses compose the central nervous system (CNS). Microglia are resident cells of the CNS and, as peripheral macrophages, are activated in presence of some cellular insult, producing a large number of cytokines and chemokines in order to remove toxins from the extracellular space. This activation can lead to a breakdown of the blood-brain barrier, production of reactive oxygen species that is involved in the progression of CNS damage as occurs in septic encephalopathy. Given the growing relevance of microglia in the area of neurotoxicology, we describe the role of microglia and the cellular mechanisms that activate these cells during sepsis. Thus, in this review we focused on the relationship between microglia and neuroinflammation associated with sepsis.
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Cite this article as:
Michels Monique, Danielski G. Lucineia, Dal-Pizzol Felipe and Petronilho Fabricia, Neuroinflammation: Microglial Activation During Sepsis, Current Neurovascular Research 2014; 11 (3) . https://dx.doi.org/10.2174/1567202611666140520122744
DOI https://dx.doi.org/10.2174/1567202611666140520122744 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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