Abstract
The over-prescription and misuse of microbiostatic or microbicidal chemical compounds led to the emergence of antibiotic resistance and multiresistance in bacterial strains. The genetic resistance of bacterial cells is amplified when they are growing in biofilms, known for the high phenotypic resistance or tolerance to antimicrobial agents, explaining their high incidence in the etiology of infectious diseases. Currently, there are many research groups in the entire world focusing their investigations on the elucidation of different aspects of bacterial intra- and intercellular communication dependent on the cellular density and regulated by the quorum-sensing and response system (QS), including the isolation of natural compounds, as well as the synthesis of biomimetic analogues or antagonists of QS molecules, with potential prophylactic and therapeutic value for the management of animal and human infections, as well as for fighting the negative consequences of biofouling phenomenon occurring in natural environments. Taking into account the vital importance of the antifouling protection of the photosyntetic organisms in the natural marine environment, the screening of marine organisms for finding new anti-pathogenic, non-lethal compounds represents a promising perspective for the development of efficient preventive and therapeutic strategies of bacterial infections produced by resistant phenotypes, associated with biofilm development.
Keywords: Biofilms, biofouling, inhibitors, marine organisms, quorum sensing.
Graphical Abstract
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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