Abstract
The present study was aimed at assessing the anti-depressant activity of the alcoholic extracts of the leaves of Alternanthera sessilis and Clerodendrum infortunatum. The activity was studied on Swiss Albino mice using the Tail Suspension Test and the Forced Swim Test, at doses of 100mg/kg b.w. and 20 mg/kg b.w. with Diazepam as the standard drug. Both the extracts, at higher dose, exhibited significant reduction in the duration of immobility. The alcoholic extract of Clerodendrum infortunatum was the most active extract in both the animal models, at a dose of 200 mg/kg b.w. Thus this study verifies the claims of antidepressant activity of these plants in the tradional medicine.
Keywords: Alternanthera sessilis, anti-depressant, clerodendrum infortunatum.
The Natural Products Journal
Title:Antidepressant Like Effects of Alternanthera sessilis and Clerodendrum infortunatum Leaves Extract in Immobility Models
Volume: 4 Issue: 1
Author(s): Rajiv Gupta and Hemant K. Singh
Affiliation:
Keywords: Alternanthera sessilis, anti-depressant, clerodendrum infortunatum.
Abstract: The present study was aimed at assessing the anti-depressant activity of the alcoholic extracts of the leaves of Alternanthera sessilis and Clerodendrum infortunatum. The activity was studied on Swiss Albino mice using the Tail Suspension Test and the Forced Swim Test, at doses of 100mg/kg b.w. and 20 mg/kg b.w. with Diazepam as the standard drug. Both the extracts, at higher dose, exhibited significant reduction in the duration of immobility. The alcoholic extract of Clerodendrum infortunatum was the most active extract in both the animal models, at a dose of 200 mg/kg b.w. Thus this study verifies the claims of antidepressant activity of these plants in the tradional medicine.
Export Options
About this article
Cite this article as:
Gupta Rajiv and K. Singh Hemant, Antidepressant Like Effects of Alternanthera sessilis and Clerodendrum infortunatum Leaves Extract in Immobility Models, The Natural Products Journal 2014; 4 (1) . https://dx.doi.org/10.2174/2210315504666140515004826
DOI https://dx.doi.org/10.2174/2210315504666140515004826 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Bone Loss and Osteoporosis are Associated with Conversion from Mild Cognitive Impairment to Alzheimer’s Disease
Current Alzheimer Research The Influence of Vitamin D on Neurodegeneration and Neurological Disorders: A Rationale for its Physio-pathological Actions
Current Pharmaceutical Design Choline Alphoscerate (Alpha-Glyceryl-Phosphoryl-Choline) An Old Choline- containing Phospholipid with a Still Interesting Profile As Cognition Enhancing Agent
Current Alzheimer Research Genetics of Cholesterol and Lipoprotein Metabolism
Recent Patents on Cardiovascular Drug Discovery Meet Our Editorial Board Member
Current Neuropharmacology Phytochemical and Biological Activities of an Anticancer Plant Medicine: Brucea javanica
Anti-Cancer Agents in Medicinal Chemistry Chiral Kinase Inhibitors
Current Topics in Medicinal Chemistry The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders
Mini-Reviews in Medicinal Chemistry Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility
Current Medicinal Chemistry Tumor Necrosis Factor Blockade for Treatment of Inflammatory Bowel Disease: Efficacy and Safety
Current Molecular Pharmacology Cell Adhesion Molecules in Gene and Cell Therapy Approaches for Nervous System Repair
Current Gene Therapy Histone Deacetylation and Motor Neuron Degeneration
CNS & Neurological Disorders - Drug Targets Current Options and Perspectives in the Treatment of Diabetic Neuropathy
Current Pharmaceutical Design EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study
Current Alzheimer Research γ-Secretase Modulation and its Promise for Alzheimers Disease: a Medicinal Chemistry Perspective
Current Topics in Medicinal Chemistry Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics
Current Medicinal Chemistry Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K/AKT Pathway
Current Neurovascular Research Oestrogen-A Protective Factor in Schizophrenia?
Current Psychiatry Reviews Xanthine Oxidase Inhibitor Febuxostat as a Novel Agent Postulated to Act Against Vascular Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Onconeural Versus Paraneoplastic Antigens?
Current Medicinal Chemistry